Role of Membrane Stretch in Adsorption of Antiviral Peptides onto Lipid Membranes and Membrane Pore Formation

Many medically important viruses are enveloped viruses, which are surrounded by a structurally conserved, host-derived lipid membrane coating. Agents that target and disrupt this membrane coating could potentially function as broad-spectrum antiviral drugs. The amphipathic α-helical (AH) peptide der...

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Bibliographic Details
Published in:Langmuir 2021-11, Vol.37 (45), p.13390-13398
Main Authors: Chng, Choon-Peng, Cho, Nam-Joon, Hsia, K. Jimmy, Huang, Changjin
Format: Article
Language:English
Subjects:
Adsorption
Antiviral Agents
Lipid Bilayers
Lipids
Membranes
Peptides
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Summary:Many medically important viruses are enveloped viruses, which are surrounded by a structurally conserved, host-derived lipid membrane coating. Agents that target and disrupt this membrane coating could potentially function as broad-spectrum antiviral drugs. The amphipathic α-helical (AH) peptide derived from the N-terminus of the hepatitis C virus NS5A protein is one such candidate and has been demonstrated to be able to selectively rupture lipid vesicles in the size range of viruses (
ISSN:0743-7463
1520-5827
DOI:10.1021/acs.langmuir.1c02067