Clinical and genomic analyses of neuroendocrine neoplasms of the breast

Breast neuroendocrine neoplasms (NENs) constitute a rare histologic subtype that includes both neuroendocrine tumors (NETs) and neuroendocrine carcinomas (NECs). In this study, we aimed to gain insight into the clinical and molecular characteristics of NENs of the breast. NEN and paired distant norm...

Full description

Saved in:
Bibliographic Details
Published in:Modern pathology 2022-04, Vol.35 (4), p.495-505
Main Authors: Wei, Yani, Ke, Xuexuan, Yu, Jiaxiu, Jing, Qiuyang, Bu, Hong, Zeng, Xiangfei, Wei, Bing
Format: Article
Language:English
Subjects:
1-Phosphatidylinositol 3-kinase
45/23
631/67/69
692/699/67/1347
Breast cancer
Breast carcinoma
Breast Neoplasms - genetics
Carcinoma, Neuroendocrine - pathology
Copy number
DNA Copy Number Variations
Female
GATA-3 protein
Genomic analysis
Genomics
Heterozygosity
Humans
Invasiveness
Laboratory Medicine
Loss of heterozygosity
MAP kinase
Medicine
Medicine & Public Health
Neoplasia
Neuroendocrine tumors
Neuroendocrine Tumors - genetics
Neuroendocrine Tumors - pathology
Pancreatic Neoplasms - pathology
Pathology
Patients
Phosphatidylinositol 3-Kinases
Signal transduction
Tumorigenesis
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Breast neuroendocrine neoplasms (NENs) constitute a rare histologic subtype that includes both neuroendocrine tumors (NETs) and neuroendocrine carcinomas (NECs). In this study, we aimed to gain insight into the clinical and molecular characteristics of NENs of the breast. NEN and paired distant normal fresh tissues and clinicopathological data were obtained from 17 patients with NENs, and clinicopathological data were collected from 755 patients with invasive breast carcinomas of no special type (IBCs-NST). We compared the clinicopathological characteristics of NENs and IBCs-NST and performed whole-exome sequencing (WES) of both NEN and paired normal tissues. Compared with the IBC-NST patients, the NEN patients had a higher mean age, lower clinical stage, and lower pathological nodal (pN) stage ( P  
ISSN:0893-3952
1530-0285
DOI:10.1038/s41379-021-00965-w