Optic nerve infiltration in systemic non Hodgkin lymphoma

Optic nerve infiltration secondary to systemic non-Hodgkin lymphoma (NHL) is a rare phenomenon. We present a 55-year-old man with low-grade systemic NHL who initially presented with an isolated optic neuropathy and non-specific neurological symptoms. We further present a literature review of systemi...

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Bibliographic Details
Published in:Orbit (Amsterdam) 2023-04, Vol.42 (2), p.216-220
Main Authors: Cameron, Cassie A, Juniat, Valerie, Tong, Jessica Y, Crompton, John L, Davis, Garry, Patel, Sandy, Selva, Dinesh
Format: Article
Language:English
Subjects:
Humans
Lymphoma - pathology
Lymphoma, Non-Hodgkin - complications
Lymphoma, Non-Hodgkin - diagnosis
Lymphoma, Non-Hodgkin - pathology
Magnetic Resonance Imaging
Male
Middle Aged
Optic Nerve - diagnostic imaging
Optic Nerve Diseases - diagnosis
Papilledema
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Summary:Optic nerve infiltration secondary to systemic non-Hodgkin lymphoma (NHL) is a rare phenomenon. We present a 55-year-old man with low-grade systemic NHL who initially presented with an isolated optic neuropathy and non-specific neurological symptoms. We further present a literature review of systemic NHL with radiological evidence of optic nerve infiltration. On magnetic resonance imaging, the characteristic features include optic nerve enhancement and enlargement, while leptomeningeal enhancement is uncommon. Cerebrospinal fluid analysis and optic nerve sheath biopsy can return false negative results, and when such investigations are inconclusive, biopsy of the optic nerve substance has a high diagnostic yield. Although rare, lymphomatous optic nerve infiltration must be considered in the differential diagnosis of a pale swollen optic disc.
ISSN:0167-6830
1744-5108
DOI:10.1080/01676830.2021.1989469