Chinese Herbal Medicine Adjusting Brain Microenvironment via Mediating Central Nervous System Lymphatic Drainage in Alzheimer’s Disease

Due to its complex pathogenesis and lack of effective therapeutic methods, Alzheimer’s disease (AD) has become a severe public health problem worldwide. Recent studies have discovered the function of central nervous system lymphatic drainage, which provides a new strategy for the treatment of AD. Ch...

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Bibliographic Details
Published in:Chinese journal of integrative medicine 2022-02, Vol.28 (2), p.176-184
Main Authors: Zhou, Xi-bin, Zhang, Yu-xing, Zhou, Chun-xiang, Ma, Jun-jie
Format: Article
Language:English
Subjects:
Alzheimer Disease - drug therapy
Amyloid beta-Peptides
Brain
China
Drugs, Chinese Herbal - therapeutic use
Humans
Medicine
Medicine & Public Health
Review
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Summary:Due to its complex pathogenesis and lack of effective therapeutic methods, Alzheimer’s disease (AD) has become a severe public health problem worldwide. Recent studies have discovered the function of central nervous system lymphatic drainage, which provides a new strategy for the treatment of AD. Chinese herbal medicine (CHM) has been considered as a cure for AD for hundreds of years in China, and its effect on scavenging β-amyloid protein in the brain of AD patients has been confirmed. In this review, the mechanism of central nervous system lymphatic drainage and the regulatory functions of CHM on correlation factors were briefly summarized. The advances in our understanding regarding the treatment of AD via regulating the central lymphatic system with CHM will promote the clinical application of CHM in AD patients and the discovery of new therapeutic drugs.
ISSN:1672-0415
1993-0402
DOI:10.1007/s11655-021-3342-5