Post-operative outcomes of inflammatory thoracic aortitis: a study of 41 patients from a cohort of 1119 surgical cases

Aortitis is found in 2–12% of thoracic aortic aneurysm repair/replacement surgeries. Yet little is known about such patients’ post-operative outcomes or the role of post-operative corticosteroids. The study was undertaken across three tertiary referral hospitals in Sydney, Australia. Prospectively c...

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Bibliographic Details
Published in:Clinical rheumatology 2022-04, Vol.41 (4), p.1219-1226
Main Authors: Caterson, Hugh C., Li, Ang, March, Lyn, Bannon, Paul G., Marshman, David, Wolfenden, Hugh D., Kench, James, Davidson, Trent, Soh, Hwei-Choo, Sammel, Anthony M.
Format: Article
Language:English
Subjects:
Adrenal Cortex Hormones - therapeutic use
Aorta, Thoracic - surgery
Aortic aneurysms
Aortitis - epidemiology
Aortitis - surgery
Arteritis
Brief Report
Cohort Studies
Corticosteroids
Female
Giant Cell Arteritis - complications
Giant Cell Arteritis - epidemiology
Giant Cell Arteritis - surgery
Histopathology
Humans
Hypertension
Immunosuppression
Inflammation
Medicine
Medicine & Public Health
Morbidity
Mortality
Patients
Rheumatology
Steroids
Surgery
Takayasu's disease
Thorax
Vein & artery diseases
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Summary:Aortitis is found in 2–12% of thoracic aortic aneurysm repair/replacement surgeries. Yet little is known about such patients’ post-operative outcomes or the role of post-operative corticosteroids. The study was undertaken across three tertiary referral hospitals in Sydney, Australia. Prospectively collected data for all thoracic aortic repair/replacement patients between 2004 and 2018 was accessed from a national surgical registry and analysed. Histopathology records identified cases of inflammatory aortitis which were subclassified as clinically isolated aortitis (CIA), giant cell arteritis (GCA), Takayasu (TAK) or other aortitis. Between-group outcomes were compared utilising logistic and median regression analyses. Between 2004 and 2018, a total of 1119 thoracic aortic surgeries were performed of which 41 (3.7%) were inflammatory aortitis cases (66% CIA, 27% GCA, 5% TAK, 2% other). Eight out of 41 (20%) aortitis patients received post-operative corticosteroids. Compared to non-aortitis patients, the aortitis group was predominantly female (53.7% vs. 28.1%, p  
ISSN:0770-3198
1434-9949
DOI:10.1007/s10067-021-05978-z