Clinical Impact of Primary Tumor Site in Stage IV Colorectal Cancer: A Statewide Cohort Study

Background/Aim: We investigated the clinical impact of the primary tumor site in stage IV colorectal cancer (CRC). Patients and Methods: In this statewide multicenter retrospective cohort, patients with stage IV CRC from nine hospital-based cancer registries across the Fukushima Prefecture (2008-201...

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Bibliographic Details
Published in:Anticancer research 2021-11, Vol.41 (11), p.5693-5702
Main Authors: Kawamura, Hidetaka, Honda, Michitaka, Takiguchi, Koichi, Kamiga, Takahiro, Saito, Katsumasa, Muto, Atsushi, Shiraso, Satoru, Yamashita, Naoyuki, Iwao, Toshiyasu, Saji, Shigehira, Kono, Koji, Konno, Shinichi
Format: Article
Language:English
Subjects:
Cohort analysis
Colon
Colon cancer
Colorectal cancer
Colorectal carcinoma
Confidence intervals
Liver cancer
Medical prognosis
Metastases
Metastasis
Patients
Rectum
Regression analysis
Statistical analysis
Survival
Tumors
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Summary:Background/Aim: We investigated the clinical impact of the primary tumor site in stage IV colorectal cancer (CRC). Patients and Methods: In this statewide multicenter retrospective cohort, patients with stage IV CRC from nine hospital-based cancer registries across the Fukushima Prefecture (2008-2015) were categorized based on three primary tumor sites: right colon cancer (RCC), left colon cancer (LCC), and rectal cancer. Overall survival was assessed using Cox regression analysis. Results: A total of 1,211 patients were included. The most common clinical symptom was obstruction in LCC and bleeding in rectal cancer. Liver metastases were multiple and larger in LCC, while lung metastases were multiple in rectal cancer. Compared to LCC, the adjusted hazard ratio (HR) for overall survival was 1.19 [95% confidence interval (CI)=1.01-1.39, p=0.032] in RCC and 1.03 (95% CI=0.86-1.23, p=0.77) in rectal cancer. Conclusion: RCC was independently associated with a worse prognosis in stage IV CRC.
ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.15385