Clinical Impact of Primary Tumor Site in Stage IV Colorectal Cancer: A Statewide Cohort Study

Background/Aim: We investigated the clinical impact of the primary tumor site in stage IV colorectal cancer (CRC). Patients and Methods: In this statewide multicenter retrospective cohort, patients with stage IV CRC from nine hospital-based cancer registries across the Fukushima Prefecture (2008-201...

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Published in:Anticancer research 2021-11, Vol.41 (11), p.5693-5702
Main Authors: Kawamura, Hidetaka, Honda, Michitaka, Takiguchi, Koichi, Kamiga, Takahiro, Saito, Katsumasa, Muto, Atsushi, Shiraso, Satoru, Yamashita, Naoyuki, Iwao, Toshiyasu, Saji, Shigehira, Kono, Koji, Konno, Shinichi
Format: Article
Language:English
Subjects:
Cohort analysis
Colon
Colon cancer
Colorectal cancer
Colorectal carcinoma
Confidence intervals
Liver cancer
Medical prognosis
Metastases
Metastasis
Patients
Rectum
Regression analysis
Statistical analysis
Survival
Tumors
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container_issue 11
container_start_page 5693
container_title Anticancer research
container_volume 41
creator Kawamura, Hidetaka
Honda, Michitaka
Takiguchi, Koichi
Kamiga, Takahiro
Saito, Katsumasa
Muto, Atsushi
Shiraso, Satoru
Yamashita, Naoyuki
Iwao, Toshiyasu
Saji, Shigehira
Kono, Koji
Konno, Shinichi
description Background/Aim: We investigated the clinical impact of the primary tumor site in stage IV colorectal cancer (CRC). Patients and Methods: In this statewide multicenter retrospective cohort, patients with stage IV CRC from nine hospital-based cancer registries across the Fukushima Prefecture (2008-2015) were categorized based on three primary tumor sites: right colon cancer (RCC), left colon cancer (LCC), and rectal cancer. Overall survival was assessed using Cox regression analysis. Results: A total of 1,211 patients were included. The most common clinical symptom was obstruction in LCC and bleeding in rectal cancer. Liver metastases were multiple and larger in LCC, while lung metastases were multiple in rectal cancer. Compared to LCC, the adjusted hazard ratio (HR) for overall survival was 1.19 [95% confidence interval (CI)=1.01-1.39, p=0.032] in RCC and 1.03 (95% CI=0.86-1.23, p=0.77) in rectal cancer. Conclusion: RCC was independently associated with a worse prognosis in stage IV CRC.
doi_str_mv 10.21873/anticanres.15385
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Patients and Methods: In this statewide multicenter retrospective cohort, patients with stage IV CRC from nine hospital-based cancer registries across the Fukushima Prefecture (2008-2015) were categorized based on three primary tumor sites: right colon cancer (RCC), left colon cancer (LCC), and rectal cancer. Overall survival was assessed using Cox regression analysis. Results: A total of 1,211 patients were included. The most common clinical symptom was obstruction in LCC and bleeding in rectal cancer. Liver metastases were multiple and larger in LCC, while lung metastases were multiple in rectal cancer. Compared to LCC, the adjusted hazard ratio (HR) for overall survival was 1.19 [95% confidence interval (CI)=1.01-1.39, p=0.032] in RCC and 1.03 (95% CI=0.86-1.23, p=0.77) in rectal cancer. Conclusion: RCC was independently associated with a worse prognosis in stage IV CRC.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>DOI: 10.21873/anticanres.15385</identifier><language>eng</language><publisher>Athens: International Institute of Anticancer Research</publisher><subject>Cohort analysis ; Colon ; Colon cancer ; Colorectal cancer ; Colorectal carcinoma ; Confidence intervals ; Liver cancer ; Medical prognosis ; Metastases ; Metastasis ; Patients ; Rectum ; Regression analysis ; Statistical analysis ; Survival ; Tumors</subject><ispartof>Anticancer research, 2021-11, Vol.41 (11), p.5693-5702</ispartof><rights>Copyright International Institute of Anticancer Research Nov 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c306t-ee18335badb55a19fcfae0a31320edf65623483561af54243fdf4b141e1d6eb43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Kawamura, Hidetaka</creatorcontrib><creatorcontrib>Honda, Michitaka</creatorcontrib><creatorcontrib>Takiguchi, Koichi</creatorcontrib><creatorcontrib>Kamiga, Takahiro</creatorcontrib><creatorcontrib>Saito, Katsumasa</creatorcontrib><creatorcontrib>Muto, Atsushi</creatorcontrib><creatorcontrib>Shiraso, Satoru</creatorcontrib><creatorcontrib>Yamashita, Naoyuki</creatorcontrib><creatorcontrib>Iwao, Toshiyasu</creatorcontrib><creatorcontrib>Saji, Shigehira</creatorcontrib><creatorcontrib>Kono, Koji</creatorcontrib><creatorcontrib>Konno, Shinichi</creatorcontrib><title>Clinical Impact of Primary Tumor Site in Stage IV Colorectal Cancer: A Statewide Cohort Study</title><title>Anticancer research</title><description>Background/Aim: We investigated the clinical impact of the primary tumor site in stage IV colorectal cancer (CRC). 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Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawamura, Hidetaka</au><au>Honda, Michitaka</au><au>Takiguchi, Koichi</au><au>Kamiga, Takahiro</au><au>Saito, Katsumasa</au><au>Muto, Atsushi</au><au>Shiraso, Satoru</au><au>Yamashita, Naoyuki</au><au>Iwao, Toshiyasu</au><au>Saji, Shigehira</au><au>Kono, Koji</au><au>Konno, Shinichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical Impact of Primary Tumor Site in Stage IV Colorectal Cancer: A Statewide Cohort Study</atitle><jtitle>Anticancer research</jtitle><date>2021-11-01</date><risdate>2021</risdate><volume>41</volume><issue>11</issue><spage>5693</spage><epage>5702</epage><pages>5693-5702</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>Background/Aim: We investigated the clinical impact of the primary tumor site in stage IV colorectal cancer (CRC). Patients and Methods: In this statewide multicenter retrospective cohort, patients with stage IV CRC from nine hospital-based cancer registries across the Fukushima Prefecture (2008-2015) were categorized based on three primary tumor sites: right colon cancer (RCC), left colon cancer (LCC), and rectal cancer. Overall survival was assessed using Cox regression analysis. Results: A total of 1,211 patients were included. The most common clinical symptom was obstruction in LCC and bleeding in rectal cancer. Liver metastases were multiple and larger in LCC, while lung metastases were multiple in rectal cancer. Compared to LCC, the adjusted hazard ratio (HR) for overall survival was 1.19 [95% confidence interval (CI)=1.01-1.39, p=0.032] in RCC and 1.03 (95% CI=0.86-1.23, p=0.77) in rectal cancer. 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subjects Cohort analysis
Colon
Colon cancer
Colorectal cancer
Colorectal carcinoma
Confidence intervals
Liver cancer
Medical prognosis
Metastases
Metastasis
Patients
Rectum
Regression analysis
Statistical analysis
Survival
Tumors
title Clinical Impact of Primary Tumor Site in Stage IV Colorectal Cancer: A Statewide Cohort Study
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