GABA molecules made by B cells can dampen antitumour responses

Analysis of immune cells shows that, unexpectedly, B cells secrete GABA, a molecule best known as a neurotransmitter. B-cell-derived GABA can modulate immune responses against tumours, raising the prospect of new therapies. B cells release the neurotransmitter GABA to tune immune responses.

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Bibliographic Details
Published in:Nature (London) 2021-11, Vol.599 (7885), p.374-376
Main Author: Kaufman, Daniel L.
Format: Article
Language:English
Subjects:
631/250
631/67
Analysis
B cells
B-Lymphocytes
Chemical synthesis
GABA
gamma-Aminobutyric Acid
Humanities and Social Sciences
Immunity
Lymphocyte Count
Methods
multidisciplinary
News And Views
Physiological aspects
Properties
Science
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Description
Summary:Analysis of immune cells shows that, unexpectedly, B cells secrete GABA, a molecule best known as a neurotransmitter. B-cell-derived GABA can modulate immune responses against tumours, raising the prospect of new therapies. B cells release the neurotransmitter GABA to tune immune responses.
ISSN:0028-0836
1476-4687
DOI:10.1038/d41586-021-02953-1