Heavy mutagenesis by tobacco leads to lung adenocarcinoma tumors with KRAS G12 mutations other than G12D, leading KRAS G12D tumors—on average—to exhibit a lower mutation burden

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Bibliographic Details
Published in:Lung cancer (Amsterdam, Netherlands) Netherlands), 2022-04, Vol.166, p.265-269
Main Authors: Tan, Chichun, Mandell, Jeffrey D., Dasari, Krishna, Cannataro, Vincent L., Alfaro-Murillo, Jorge A., Townsend, Jeffrey P.
Format: Article
Language:English
Subjects:
Adenocarcinoma - genetics
Adenocarcinoma - pathology
Adenocarcinoma of Lung - genetics
Humans
Lung Neoplasms - genetics
Lung Neoplasms - pathology
Mutagenesis
Mutation
Proto-Oncogene Proteins p21(ras) - genetics
Tobacco Products
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ISSN:0169-5002
1872-8332
1872-8332
DOI:10.1016/j.lungcan.2021.10.008