Organ donor management goals and delayed graft function in adult kidney transplant recipients

• Published in: Clinical transplantation 2022-02, Vol.36 (2), p.e14528-n/a
• Main Authors: Kothari, Rishi, Tolles, Juliana, Adelmann, Dieter, Lewis, Roger J., Malinoski, Darren J., Niemann, Claus U.
• Format: Article
• Language: English
• Subjects: Adult; Case-Control Studies; critical care; delayed graft function; Delayed Graft Function - epidemiology; Delayed Graft Function - etiology; donor management; Goals; Graft Survival; Humans; kidney transplantation; Kidney Transplantation - adverse effects; Retrospective Studies; Risk Factors; tissue and organ procurement; Tissue Donors
• ISSN: 0902-0063; 1399-0012
• DOI: 10.1111/ctr.14528

Background Delayed graft function (DGF) after kidney transplantation is a common occurrence and correlates with poor graft and patient outcomes. Donor characteristics and care are known to impact DGF. We attempted to show the relationship between achievement of specific donor management goals (DMG) and DGF. Methods This is a retrospective case‐control study using data from 14 046 adult kidney donations after brain death from hospitals in 18 organ procurement organizations (OPOs) which were transplanted to adult recipients between 2012 and 2018. Data on DMG compliance and donor, recipient, and ischemia‐related factors were used to create multivariable logistic regression models. Results The overall rate of DGF was 29.4%. Meeting DMGs for urine output and vasopressor use were associated with decreased risk of DGF. Sensitivity analyses performed with different imputation methods, omitting recipient factors, and analyzing multiple time points yielded largely consistent results. Conclusions The development of DMGs continues to show promise in improving outcomes in the kidney transplant recipient population. Studies have already shown increased kidney utilization in smaller cohorts, as well as other organs, and shown decreased rates of DGF. Additional research and analysis are required to assess interactions between meeting DMGs and correlation versus causality in DMGs and DGF.