Enhancing microbial lipids yield for biodiesel production by oleaginous yeast Lipomyces starkeyi fermentation: A review

[Display omitted] •Key technical issues for hindering lipids production by L. starkeyi are identified.•Six promising strategies for enhancing lipid yield and productivity are discussed.•Examination of more gene targets via metabolic engineering deserves investigation.•Development of inhibitor-tolera...

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Bibliographic Details
Published in:Bioresource technology 2022-01, Vol.344 (Pt B), p.126294-126294, Article 126294
Main Authors: Zhang, Le, Lee, Jonathan T.E., Ok, Yong Sik, Dai, Yanjun, Tong, Yen Wah
Format: Article
Language:English
Subjects:
Biofuels
Bioprocess engineering
Fermentation
Intensification strategies
Lipid production
Lipids
Lipomyces
Metabolic engineering
Microbial biodiesel
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Summary:[Display omitted] •Key technical issues for hindering lipids production by L. starkeyi are identified.•Six promising strategies for enhancing lipid yield and productivity are discussed.•Examination of more gene targets via metabolic engineering deserves investigation.•Development of inhibitor-tolerating strain & two-stage fermentation are promising.•Oleaginous yeast-algae co-cultivation and parameter optimization are recommended. The enhanced production of microbial lipids suitable for manufacturing biodiesel from oleaginous yeast Lipomyces starkeyi is critically reviewed. Recent advances in several aspects involving the biosynthetic pathways of lipids, current conversion efficiencies using various carbon sources, intensification strategies for improving lipid yield and productivity in L. starkeyi fermentation, and lipid extraction approaches are analyzed from about 100 papers for the past decade. Key findings on strategies are summarized, including (1) optimization of parameters, (2) cascading two-stage systems, (3) metabolic engineering strategies, (4) mutagenesis followed by selection, and (5) co-cultivation of yeast and algae. The current technical limitations are analyzed. Research suggestions like examination of more gene targets via metabolic engineering are proposed. This is the first comprehensive review on the latest technical advances in strategies from the perspective of process and metabolic engineering to further increase the lipid yield and productivity from L. starkeyi fermentation.
ISSN:0960-8524
1873-2976
DOI:10.1016/j.biortech.2021.126294