Surgical treatments for obstructive sleep apnea decrease the risk of erectile dysfunction: A nationwide cohort study

• Published in: Andrology (Oxford) 2022-03, Vol.10 (3), p.477-485
• Main Authors: Hwang, Juen‐Haur, Ong, Hueih‐Ling, Chen, Yi‐Chun
• Format: Article
• Language: English
• Subjects: Cohort analysis; cohort study; Erectile dysfunction; obstructive sleep apnea; propensity score; Sleep apnea; surgical treatment
• ISSN: 2047-2919; 2047-2927
• DOI: 10.1111/andr.13126

Background It has been reported that the risk of erectile dysfunction (ED) is significantly higher in patients with obstructive sleep apnea (OSA), compared with patients without OSA. However, there is limited evidence on whether surgical treatments in patients with OSA could decrease ED risk. Objectives To assess the impact of surgical treatments for OSA on the risk of ED by analysis of claims data from the Taiwan National Health Insurance Research Database between 1997 and 2012. Material and methods We identified 20,675 male adults with newly diagnosed OSA during the study period; 16,040 patients ever received surgical treatments (treated cohort) and 4635 patients never received surgical treatments (untreated cohort). According to 3:1 propensity score matching, we analyzed 8337 patients in the treated cohort and 2779 controls in the untreated cohort. We estimated the incidence rates (IRs) and hazard ratios (HRs) of incident ED in both cohorts through the end of 2012. Results In a total study follow‐up of 64,916 person‐years, 396 (3.6%) patients developed impotence. The IRs of ED for the treated and untreated cohorts, respectively, were 55.8 (95% confidence interval [CI], 55.6–55.9) and 76.1 (95% CI, 76.0–76.3) per 1000 person‐years. Multivariate Cox proportional hazard analysis showed that surgical treatments for OSA patients were associated with a lower risk for ED (adjusted HR, 0.79; 95% CI, 0.64–0.98). Multivariate stratified analysis further verified that significant risk reduction of ED was present in OSA patients without hypertension, diabetes, hyperlipidemia, hyperuricemia, obesity, chronic kidney disease, and chronic liver disease. Conclusions We found that OSA patients who received surgical treatments were associated with a lower risk for developing ED by 21%.