Plasmodium vivax gametocytes and transmission

Malaria elimination means cessation of parasite transmission. At present, the declining malaria incidence in many countries has made elimination a feasible goal. Transmission control has thus been placed at the center of the national malaria control programs. The efficient transmission of Plasmodium...

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Bibliographic Details
Published in:Parasitology international 2022-04, Vol.87, p.102497-102497, Article 102497
Main Authors: Bantuchai, Sirasate, Imad, Hisham, Nguitragool, Wang
Format: Article
Language:English
Subjects:
Animals
Anopheles - parasitology
Asymptomatic
Female
Gametocytes
Humans
Infectivity
Malaria, Vivax - immunology
Malaria, Vivax - parasitology
Malaria, Vivax - transmission
Male
Membrane feeding
Mosquito Vectors - parasitology
Parasitemia - parasitology
Parasitemia - transmission
Plasmodium vivax
Plasmodium vivax - physiology
Transmission
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Summary:Malaria elimination means cessation of parasite transmission. At present, the declining malaria incidence in many countries has made elimination a feasible goal. Transmission control has thus been placed at the center of the national malaria control programs. The efficient transmission of Plasmodium vivax from humans to mosquitoes is a key factor that helps perpetuate malaria in endemic areas. A better understanding of transmission is crucial to the success of elimination efforts. Biological delineation of the parasite transmission process is important for identifying and prioritizing new targets of intervention. Identification of the infectious parasite reservoir in the community is key to devising an effective elimination strategy. Here we describe the fundamental characteristics of P. vivax gametocytes - the dynamics of their production, longevity, and the relationship with the total parasitemia - as well as recent advances in the molecular understanding of parasite sexual development. In relation to malaria elimination, factors influencing the human infectivity and the current evidence for a role of asymptomatic carriers in transmission are presented.
ISSN:1383-5769
1873-0329
DOI:10.1016/j.parint.2021.102497