Advancing disease monitoring of amyotrophic lateral sclerosis with the compound muscle action potential scan

Highlights•Compound muscle action potential scan-derived markers are sensitive to track disease progression in amyotrophic lateral sclerosis. •Motor unit number estimation was most sensitive and may increase efficiency of clinical trials compared to clinical endpoints. •Standardization of compound m...

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Bibliographic Details
Published in:Clinical neurophysiology 2021-12, Vol.132 (12), p.3152-3159
Main Authors: Sleutjes, Boudewijn T.H.M, Bystrup Jacobsen, Anna, Tankisi, Hatice, Gorkem Sirin, N, Emre Oge, A, Henderson, Robert D, van Doorn, Pieter A, van den Berg, Leonard H, van Eijk, Ruben P.A
Format: Article
Language:English
Subjects:
Action Potentials
Adult
Aged
Amyotrophic Lateral Sclerosis - diagnosis
Amyotrophic Lateral Sclerosis - physiopathology
Clinical trials
Clinical Trials as Topic
Compound muscle action potential scan
Electromyography - methods
Electrophysiological markers
Female
Humans
Male
Middle Aged
Monitoring disease progression
Motor unit number estimation
Motor unit sizes
Muscle, Skeletal - innervation
Muscle, Skeletal - physiopathology
Neurology
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Summary:Highlights•Compound muscle action potential scan-derived markers are sensitive to track disease progression in amyotrophic lateral sclerosis. •Motor unit number estimation was most sensitive and may increase efficiency of clinical trials compared to clinical endpoints. •Standardization of compound muscle action potential scans can further maximize its utility for clinical use and research.
ISSN:1388-2457
1872-8952
DOI:10.1016/j.clinph.2021.09.014