Frequent EGFR Mutations and Better Prognosis in Positron Emission Tomography-Negative, Solid-Type Lung Cancer

• Published in: Clinical lung cancer 2022-01, Vol.23 (1), p.e60-e68
• Main Authors: Suda, Kenichi, Ohara, Shuta, Fujino, Toshio, Hamada, Akira, Chiba, Masato, Shimoji, Masaki, Takemoto, Toshiki, Soh, Junichi, Mitsudomi, Tetsuya
• Format: Article
• Language: English
• Subjects: Adenocarcinoma of Lung - diagnosis; Adenocarcinoma of Lung - pathology; Aged; Aged, 80 and over; Epidermal growth factor receptor (EGFR) mutation; ErbB Receptors - genetics; Female; Ground-glass opacity (GGO); Humans; Lung adenocarcinoma; Lung Neoplasms - diagnostic imaging; Lung Neoplasms - genetics; Male; Middle Aged; Mutation; Neoplasm Staging; Positron Emission Tomography Computed Tomography; Prognosis; Prognostic factors; Propensity score matching; SUVmax
• ISSN: 1525-7304; 1938-0690
• DOI: 10.1016/j.cllc.2021.10.003

The differential diagnosis of a solitary solid-type lung nodule is diverse. 18F-fluorodeoxyglucose positron emission tomography (PET) has a high sensitivity in the diagnosis of solid-type lung cancers; however, PET-negative, solid-type lung cancers are rarely observed. In this study, we analyzed the clinical/genetic features and prognosis of PET-negative, solid-type lung cancers. Between January 2007 and February 2020, 709 patients with solid-type lung cancers (tumor size ≥2.0 cm) underwent pulmonary resection. Clinical, genetic, and prognostic features were evaluated in 27 patients (3.8%) with tumors showing negative PET results defined as SUVmax