Cavitas electrochemical sensors for the direct determination of salivary thiocyanate levels

Noninvasive diagnosis using salivary samples to detect thiocyanate provides vital information on individual health. This article demonstrates the first example of a wearable sensing device to noninvasively assess thiocyanate levels. The customized screen-printed electrode system is integrated into a...

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Bibliographic Details
Published in:Mikrochimica acta (1966) 2021-12, Vol.188 (12), p.415-415, Article 415
Main Authors: Sangsawang, Rachanon, Buranachai, Chongdee, Thavarungkul, Panote, Kanatharana, Proespichaya, Jeerapan, Itthipon
Format: Article
Language:English
Subjects:
Analysis
Analytical Chemistry
Biofouling
Biomarkers
Biomarkers - analysis
Biomedical engineering
Biosensing Techniques - instrumentation
Blood
Characterization and Evaluation of Materials
Chemical sensors
Chemistry
Chemistry and Materials Science
Cyanides - chemistry
Cyanides - toxicity
Diagnosis
Electrochemical Techniques - instrumentation
Electrodes
Environmental Exposure
Humans
Innovations
Medical examination
Microengineering
Monitoring, Physiologic
Mouthguards
Nanochemistry
Nanotechnology
Original Paper
Saliva - chemistry
Selectivity
Sensors
Silver chloride
Smoking
Thiocyanates
Thiocyanates - chemistry
Voltammetry
Wearable Electronic Devices
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Summary:Noninvasive diagnosis using salivary samples to detect thiocyanate provides vital information on individual health. This article demonstrates the first example of a wearable sensing device to noninvasively assess thiocyanate levels. The customized screen-printed electrode system is integrated into a form of a mouthguard squarewave-voltammetric sensor toward the convenient and fast detection of the salivary biomarker within 15 s. The sensor with a protective film to mitigate the effect of biofouling offers high sensitivity and selectivity toward the detection of thiocyanate ions. Partial least square regression is applied to analyze the high-order squarewave-voltammetric data over the applied potential range of 0–1.75 V vs Ag/AgCl and quantify the thiocyanate concentration in a complex matrix. The mouthguard sensor operating under physiological conditions can monitor a wide range of thiocyanate (up to 11 mM) with a low detection limit of 30 µM. The demonstration introduces a unique approach, that obviates the requirement for blood sampling, to study thiocyanate levels of healthy people, cigarette smokers, or people with other health conditions. It is envisioned that the new cavitas device possesses a substantial promise for diverse biomedical diagnosis applications. Graphical abstract
ISSN:0026-3672
1436-5073
DOI:10.1007/s00604-021-05067-7