Baseline or 90-day fibrinogen levels and long-term outcomes after ischemic stroke or TIA: Results from the China national stroke registry

Elevated fibrinogen levels have been observed in patients with acute ischemic stroke, but the association of fibrinogen with stroke outcomes is still undefined. We aimed to assess the association between baseline or 90-day fibrinogen levels and long-term outcomes in patients with ischemic stroke or...

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Bibliographic Details
Published in:Atherosclerosis 2021-11, Vol.337, p.35-41
Main Authors: Hou, Hui-Qing, Xiang, Xiang-Long, Pan, Yue-Song, Zhang, Qi-Hui, Li, Hao, Meng, Xia, Wang, Yong-Jun
Format: Article
Language:English
Subjects:
Fibrinogen
Outcome
Risk factor
Stroke
Transient ischemic attack
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Summary:Elevated fibrinogen levels have been observed in patients with acute ischemic stroke, but the association of fibrinogen with stroke outcomes is still undefined. We aimed to assess the association between baseline or 90-day fibrinogen levels and long-term outcomes in patients with ischemic stroke or transient ischemic attack (TIA). Using data from the China National Stroke Registry Ⅲ, this substudy included 10 518 patients within 7 days (baseline) of onset and 6268 patients at 90 days of recovery. Multivariate Cox regression and logistic regression analyses were used to assess the associations of fibrinogen with poor functional outcome (modified Rankin Scale score 3–6), dependence (modified Rankin Scale score 3–5), all-cause death, and stroke recurrence at 1 year. Fibrinogen levels at 90 days were higher than those at baseline (443.5 mg/dl versus 393.7 mg/dl; p 
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2021.10.002