Correlation between leukocyte‐platelet aggregates and thrombosis in myeloproliferative neoplasms

Introduction The impact of activated blood and endothelial cells on the thrombosis in myeloproliferative neoplasms (MPN) has not yet been clarified. We prospectively analyzed correlation between circulating leukocyte‐platelet aggregates and soluble selectins to thrombosis occurrence in MPN, in the c...

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Published in:International journal of laboratory hematology 2022-04, Vol.44 (2), p.302-312
Main Authors: Šefer, Dijana, Miljić, Predrag, Kraguljac‐Kurtović, Nada, Bižić‐Radulović, Sandra, Bogdanović, Andrija, Knežević, Vesna, Marković, Dragana, Beleslin‐Čokić, Bojana, Novaković, Ivana, Marinković, Jelena, Leković, Danijela, Gotić, Mirjana, Čokić, Vladan
Format: Article
Language:English
Subjects:
Blood platelets
Cardiovascular diseases
Endothelial cells
Enzyme immunoassay
Flow cytometry
Leukocytes (neutrophilic)
Monocytes
myeloproliferative neoplasms
Patients
Peripheral blood
platelet activation
Platelets
Risk factors
Selectins
Thrombosis
Tumors
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Summary:Introduction The impact of activated blood and endothelial cells on the thrombosis in myeloproliferative neoplasms (MPN) has not yet been clarified. We prospectively analyzed correlation between circulating leukocyte‐platelet aggregates and soluble selectins to thrombosis occurrence in MPN, in the context of standard and cardiovascular risk factors, and different clinical and biological characteristics. Methods Flow cytometric analysis of neutrophil‐platelet (Neu‐Plt) and monocyte‐platelet (Mo‐Plt) aggregates in peripheral blood, as well as quantification of soluble E‐/L‐/P‐selectins by enzyme immunoassay, was performed on 95 newly diagnosed MPN patients. Results During the follow‐up, thrombosis occurred in 12.6% MPN patients (arterial 9.4%, venous 3.2%), with a mean time of 39 months. The overall incidence rate of main thrombotic events was 4.36 per 100 patient‐years. The incidence of arterial hypertension (HTA) was significantly higher in patients with thrombosis, compared to those without thrombosis (P 
ISSN:1751-5521
1751-553X
DOI:10.1111/ijlh.13754