Erythematous Papules and Hemorrhagic Vesicles in a Woman With Arthralgias and Eye Pain

A 48-year-old woman with diet-controlled diabetes had extremity arthralgias, a purpuric rash and foot paresthesias, and eye pain and redness. Vital signs and results of laboratory testing including direct immunofluorescence were unremarkable; skin biopsy showed leukocytoclasia, erythrocytic extravas...

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Bibliographic Details
Published in:JAMA : the journal of the American Medical Association 2021-12, Vol.326 (22), p.2314-2315
Main Authors: West, Lindsey, Cho, Sung Kyung, Thomas, Cristina
Format: Article
Language:English
Subjects:
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - blood
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - complications
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - diagnosis
Antibodies, Antineutrophil Cytoplasmic - blood
Arthralgia - etiology
Biopsy
Blister - etiology
Blood vessels
Diabetes mellitus
Diagnosis, Differential
Extravasation
Eye Pain - etiology
Female
Fibrin
Hemorrhage
Hemorrhage - etiology
Humans
Immunofluorescence
Laboratory tests
Middle Aged
Pain
Citations: Items that this one cites
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Description
Summary:A 48-year-old woman with diet-controlled diabetes had extremity arthralgias, a purpuric rash and foot paresthesias, and eye pain and redness. Vital signs and results of laboratory testing including direct immunofluorescence were unremarkable; skin biopsy showed leukocytoclasia, erythrocytic extravasation, and fibrin in small blood vessel walls. What is the diagnosis and what would you do next?
ISSN:0098-7484
1538-3598
DOI:10.1001/jama.2021.18708