Structurally screening calixarenes as peptide transport activators

Calixarenes are reportedly excellent activators that can remarkably improve the transport efficiencies of cell penetrating peptides. We employed eight calixarenes to systematically study the influence of structure on activation efficiency, which revealed that the scaffold, head group, and alkyl chai...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2021-11, Vol.57 (94), p.12627-1263
Main Authors: Zhang, De-Yi, Zheng, Zhe, Zhao, Hong, Wang, Huan-Yu, Ding, Fei, Li, Hua-Bin, Pan, Yu-Chen, Guo, Dong-Sheng
Format: Article
Language:English
Subjects:
Biological Transport - drug effects
Calixarenes
Calixarenes - chemistry
Calixarenes - pharmacology
Drug Evaluation, Preclinical
Humans
Molecular Structure
Peptides
Peptides - metabolism
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Summary:Calixarenes are reportedly excellent activators that can remarkably improve the transport efficiencies of cell penetrating peptides. We employed eight calixarenes to systematically study the influence of structure on activation efficiency, which revealed that the scaffold, head group, and alkyl chain are all significant factors for activation efficiency by affecting affinities with the peptide and membrane. We studied the influence of calixarene structure on transport efficiency of peptides, and provide meaningful information for transport systems.
ISSN:1359-7345
1364-548X
DOI:10.1039/d1cc05414g