Left bundle branch pacing in heart failure patients with left bundle branch block: A systematic review and meta‐analysis

Background The clinical benefit of cardiac resynchronization therapy (CRT) in heart failure patients with left bundle branch block (LBBB) has been demonstrated. However, a nonresponse rate of CRT nearly 1/3. Recent studies have reported left bundle branch pacing (LBBP) has achieved remarkable effect...

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Bibliographic Details
Published in:Pacing and clinical electrophysiology 2022-02, Vol.45 (2), p.212-218
Main Authors: Cheng, Yuda, Wang, Zhanqi, Li, Yujun, Qi, Jinlei, Liu, Jinyu
Format: Article
Language:English
Subjects:
biventricular pacing
Bundle-Branch Block - complications
Bundle-Branch Block - therapy
Cardiac Pacing, Artificial - methods
cardiac resynchronization therapy
Classification
Clinical trials
Congestive heart failure
Heart failure
Heart Failure - complications
Heart Failure - therapy
Humans
left bundle branch block
left bundle branch pacing
Meta-analysis
Patients
Ventricle
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Summary:Background The clinical benefit of cardiac resynchronization therapy (CRT) in heart failure patients with left bundle branch block (LBBB) has been demonstrated. However, a nonresponse rate of CRT nearly 1/3. Recent studies have reported left bundle branch pacing (LBBP) has achieved remarkable effect in CRT. This study aim to explore the efficacy and safety of LBBP in heart failure patients with LBBB. Methods We searched PubMed, Cochrane Library, Web of science, and CNKI databases for studies about LBBP in heart failure patients with LBBB. QRS duration (QRSd), New York Heart Association (NYHA) classification, B‐type natriuretic peptide (BNP) concentration, left ventricular ejection fraction (LVEF), left ventricular end‐diastolic diameter (LVEDD), pacing threshold and other related data were extracted and summarized. Results A total of 6 studies were included, and the success rate of LBBP was 93.2%. Compared with baseline, LBBP could shorten QRSd (MD = 61.23, 95% CI: 58.21–64.25, p 
ISSN:0147-8389
1540-8159
DOI:10.1111/pace.14405