Breast-conserving therapy for breast cancer with BRCA mutations: a meta-analysis

Background BRCA1/2 mutated breast cancer accounts for 3 to 12% of all women with breast cancer and significantly increases the lifetime risk of breast cancer. However, the optimal local treatment for breast cancer with BRCA germline mutation remains controversial. Here we present a meta-analysis to...

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Bibliographic Details
Published in:Breast cancer (Tokyo, Japan) Japan), 2022-03, Vol.29 (2), p.314-323
Main Authors: Wang, Changjun, Lin, Yan, Zhu, Hanjiang, Zhou, Yidong, Mao, Feng, Huang, Xin, Zhou, Xingtong, Cao, Xi, Sun, Qiang
Format: Article
Language:English
Subjects:
Analysis
Breast cancer
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Breast Neoplasms - surgery
Cancer
Cancer Research
Care and treatment
Female
Gene mutations
Genetic aspects
Health aspects
Humans
Lumpectomy
Mastectomy - methods
Mastectomy, Segmental
Medicine
Medicine & Public Health
Mutation
Oncology
Oncology, Experimental
Original Article
Prognosis
Surgery
Surgical Oncology
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Summary:Background BRCA1/2 mutated breast cancer accounts for 3 to 12% of all women with breast cancer and significantly increases the lifetime risk of breast cancer. However, the optimal local treatment for breast cancer with BRCA germline mutation remains controversial. Here we present a meta-analysis to evaluate the impact of breast-conserving therapy (BCT) on the prognosis of breast cancer with BRCA mutation. Methods Two independent reviewers searched Pubmed, Embase and Cochrane Central Register of Controlled Trials databases for relevant studies on BCT and BRCA mutated breast cancer. Fixed or random effect models were used for meta-analyses based on whether significant heterogeneity existed among included studies. Funnel plot and Begg’s test were employed for the evaluation of publication bias. Results Totally, four studies with five cohorts and a totally 1254 patients were included for meta-analyses. The BCT group involved more T0/T1 (BCT 63.7% Vs. M 48.9%, p  
ISSN:1340-6868
1880-4233
DOI:10.1007/s12282-021-01312-2