Subjective, neuropsychological, and neural markers of memory in older adults

To investigate the relationship between the P300 event-related potential, neuropsychological measures of memory, subjective memory complaints (SMCs), and indicators of psychosocial functioning. In this cross-sectional study of 79 community-based older adults, aged 60–75 years, participants completed...

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Bibliographic Details
Published in:International psychogeriatrics 2022-12, Vol.34 (12), p.1035-1043
Main Authors: Sheffler, Julia L., Meynadasy, Melissa A., Taylor, Diamond T., Kiosses, Dimitris N., Hajcak, Greg
Format: Article
Language:English
Subjects:
Adult
Adults
Aged
Alzheimer's disease
Anxiety
Clinical interviews
Cognitive ability
cognitive functioning
Cognitive impairment
Complaints
Cross-Sectional Studies
Dementia
Electroencephalography
Emotions
Event-related potentials
Geriatrics
Humans
Memory
Mental depression
Metamemory
Neurocognition
Neuropsychology
Older people
Original Research Article
P300 ERP
Psychological Well-Being
Psychosocial factors
Psychosocial functioning
Questionnaires
Stress
subjective memory complaints
Verbal memory
Well being
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Summary:To investigate the relationship between the P300 event-related potential, neuropsychological measures of memory, subjective memory complaints (SMCs), and indicators of psychosocial functioning. In this cross-sectional study of 79 community-based older adults, aged 60–75 years, participants completed online surveys and in-person neuropsychological and electroencephalogram (EEG) assessments. Measures included: the Change subscale of the Metamemory in Adulthood Questionnaire, NIH Toolbox Emotions battery (Perceived Stress and Psychological Well-Being), Geriatric Depression Scale, Geriatric Anxiety Scale, electrocortical measures (EEG), California Verbal Learning Test, 3rd Edition, and diagnostic ratings for mild and major neurocognitive disorders based on full neuropsychological battery, clinical interview, and two-clinician consensus. P300 amplitude was associated with long-delay verbal memory recall and diagnostic rating. SMCs were not associated with objective memory or diagnostic rating. SMCs were associated with higher perceived stress, anxiety, and depression symptoms and lower psychological well-being. Neural indicators such as the P300 may be useful for early detection of cognitive impairment. SMCs were not a reliable indicator of early memory impairment in relation to neuropsychological or neural indicators, but may be a useful indicator of unreported stress and mood symptoms in clinical settings.
ISSN:1041-6102
1741-203X
DOI:10.1017/S1041610221002623