N6-Methyladenosine Methylation of mRNA in Cell Senescence

Cell senescence is the growth arrest caused by the accumulation of irreparable cell damage, which is involved in physiological and pathological processes and regulated by the post-transcriptional level. This regulation is performed by transcriptional regulators and driven by aging-related small RNAs...

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Bibliographic Details
Published in:Cellular and molecular neurobiology 2023-01, Vol.43 (1), p.27-36
Main Authors: Zhang, Lin, Xia, Jian
Format: Article
Language:English
Subjects:
Aging
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cellular Senescence - genetics
Chemical modification
Gene regulation
Methylation
N6-methyladenosine
Neurobiology
Neurosciences
Post-transcription
Review Paper
RNA modification
RNA, Messenger - genetics
RNA, Messenger - metabolism
RNA-binding protein
RNA-Binding Proteins - genetics
RNA-Binding Proteins - metabolism
Senescence
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Summary:Cell senescence is the growth arrest caused by the accumulation of irreparable cell damage, which is involved in physiological and pathological processes and regulated by the post-transcriptional level. This regulation is performed by transcriptional regulators and driven by aging-related small RNAs, long non-coding RNAs, and RNA-binding proteins. N6-methyladenosine (m 6 A) is the most common chemical modification in eukaryotic mRNA, which can enhance or reduce the binding of transcriptional regulators. Increasing studies have confirmed the crucial role of m 6 A in controlling mRNA in various physiological processes. Remarkably, recent reports have indicated that abnormal methylation of m 6 A-related RNA may affect cell senescence. In this review, we clarified the association between m 6 A modification and cell senescence and analyzed the limitations of the current research.
ISSN:0272-4340
1573-6830
DOI:10.1007/s10571-021-01168-2