History of urological malignancies before kidney transplantation, oncological outcome on the long term

• Published in: Actas urológicas españolas (English ed.) 2021-12, Vol.45 (10), p.623-634
• Main Authors: Boissier, R., Hidalgo, R., Rodríguez Faba, O., Territo, A., Subiela, J.D., Huguet, J., Sánchez-Puy, A., Gallioli, A., Vanacore, D., Mercade, A., Martinez, C., Palou, J., Guirado, L., Breda, A.
• Format: Article
• Language: English
• Subjects: Carcinoma de células renales; Carcinoma urotelial del tracto urinario superior; Cáncer de próstata; Cáncer de testículo; Cáncer de vejiga no músculo invasivo; Humans; Kidney Failure, Chronic; Kidney Transplantation; Male; Neoplasm Recurrence, Local; Non-muscle invasive bladder cancer; Prostate cancer; Renal cell carcinoma; Retrospective Studies; Testicular cancer; Trasplante de riñón; Upper urinary tract urothelial carcinoma; Urologic Neoplasms - epidemiology; Urologic Neoplasms - therapy
• ISSN: 2173-5786; 2173-5786
• DOI: 10.1016/j.acuroe.2020.10.016

We aimed to report the oncological outcomes of ESRD patients with histories of urological malignancies who were subsequently submitted to kidney transplantation (KT). Retrospective study lead in the Puigvert Foundation (Barcelona) registry of 1,200 KT performed from 1988 to 2018. Eighty-five urological malignancies that were treated before KT in 81 patients were identified: 15 (18%) prostate cancers, 49 (58%) RCC, 19 (22%) urothelial carcinomas and 2 (2%) testicular cancers. Baseline characteristics, cancer staging, treatment and follow-up were registered as well as the chronology of the start of dialysis, inscription on the waiting list and kidney transplantation. Endpoints included were cancer recurrence, metastatic progression, cancer-specific death and overall survival. In a median follow-up of 13.1 years (2.2–32), 16/85 (19%) cancer recurrences were reported, with 3 (4%) who progressed to metastasis and died of cancer. Median overall survival after cancer treatment was 25.3 years and cancer-specific survival was 95% at 25 years. Median time from cancer treatment to kidney transplantation was 4.8 years: 3.7 years in prostate cancer, 3.9 years in RCC and 8.8 years in bladder cancer. The median time from start of dialysis to kidney transplantation was 1.8 years in patients with histories of urological malignancy versus 0.5 year in the total cohort of 1,200 renal transplanted over the same period. Well-selected patients with histories of urological malignancies greatly benefit from kidney transplantation with infrequent and late cancer recurrence. Waiting time could be optimized in low-risk prostate cancer and RCC, but more robust data are needed. Nuestro objetivo ha sido informar los resultados oncológicos de pacientes con ERET y antecedentes de neoplasias urológicas que fueron sometidos posteriormente a un trasplante renal (TR). Estudio retrospectivo llevado a cabo en el registro de la Fundación Puigvert (Barcelona) con 1.200 TR realizados entre 1988 y 2018. Se identificaron 85 neoplasias urológicas que recibieron tratamiento previo al TR en 81 pacientes: 15 (18%) cánceres de próstata, 49 (58%) CCR, 19 (22%) carcinomas uroteliales y 2 (2%) cánceres de testículo. Se registraron datos de las características basales, la estadificación del cáncer, el tratamiento y el seguimiento, y sobre la cronología del inicio de diálisis, la inscripción en la lista de espera y el trasplante renal. Los criterios de valoración fueron la recidiva del cáncer, la progresión m