Insights into the chemistry and therapeutic potential of acrylonitrile derivatives

Acrylonitrile is a fascinating scaffold widely found in many natural products, drugs, and drug candidates with various biological activities. Several drug molecules such as entacapone, rilpivirine, teriflunomide, and so forth, bearing an acrylonitrile moiety have been marketed. In this review, diver...

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Bibliographic Details
Published in:Archiv der Pharmazie (Weinheim) 2022-03, Vol.355 (3), p.e2100383-n/a
Main Authors: Unsal Tan, Oya, Zengin, Merve
Format: Article
Language:English
Subjects:
Acrylonitrile
biological activities
Structure-Activity Relationship
synthesis
β‐unsaturated nitrile
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Summary:Acrylonitrile is a fascinating scaffold widely found in many natural products, drugs, and drug candidates with various biological activities. Several drug molecules such as entacapone, rilpivirine, teriflunomide, and so forth, bearing an acrylonitrile moiety have been marketed. In this review, diverse synthetic strategies for constructing desired acrylonitriles are discussed, and the different biological activities and medicinal significance of various acrylonitrile derivatives are critically evaluated. The information gathered is expected to provide rational guidance for the development of clinically useful agents from acrylonitriles. Acrylonitrile is a fascinating scaffold found in many natural products, drugs, and drug candidates. In this review, diverse synthetic strategies for the construction of desired acrylonitriles are discussed. The different biological activities and medicinal significance of various acrylonitrile derivatives are evaluated to provide rational guidance for further development of clinically useful agents from acrylonitriles.
ISSN:0365-6233
1521-4184
DOI:10.1002/ardp.202100383