Synthesis of Dihydrochromeno[2,3‑b]indoles via an Fe(OTf)3‑Catalyzed Cascade Reaction

A tandem cyclization between 2-(2-aminophenyl)­acetonitriles and 2-(hydroxy­(aryl)­methyl)­phenols for the preparation of dihydrochromeno­[2,3-b]­indole derivatives was successfully developed. The transformation proceeded smoothly in the presence of a catalytic environmentally benign iron salt, and...

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Bibliographic Details
Published in:Journal of organic chemistry 2021-12, Vol.86 (23), p.16795-16805
Main Authors: Xiao, Xi, Lu, Xiaobiao, Zhang, Ming, Hou, Haoqing, Wan, Changfeng, Liu, Jinbiao
Format: Article
Language:English
Subjects:
Catalysis
Cyclization
Indoles
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Summary:A tandem cyclization between 2-(2-aminophenyl)­acetonitriles and 2-(hydroxy­(aryl)­methyl)­phenols for the preparation of dihydrochromeno­[2,3-b]­indole derivatives was successfully developed. The transformation proceeded smoothly in the presence of a catalytic environmentally benign iron salt, and various multisubstituted dihydrochromeno­[2,3-b]­indoles were synthesized in moderate to high yields.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.1c02006