Loading…
The changes in retinal nerve fiber layer and macular thickness in Chinese patients with alcohol dependency
This study examined the changes in the retinal nerve fiber layer (RNFL) thickness and the macular thickness in Chinese patients with alcohol dependency and ascertaining the influence of optic cup volume on cognitive functioning. A total of 26 alcohol-dependent patients and 53 age- and gender-matched...
Saved in:
| Published in: | Drug and alcohol dependence 2021-12, Vol.229 (Pt B), p.109130-109130, Article 109130 |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c402t-4716106c4b6ebd1aaff12b48e38d8b768553a2e19638f09ff787e899ab8f0df83 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c402t-4716106c4b6ebd1aaff12b48e38d8b768553a2e19638f09ff787e899ab8f0df83 |
| container_end_page | 109130 |
| container_issue | Pt B |
| container_start_page | 109130 |
| container_title | Drug and alcohol dependence |
| container_volume | 229 |
| creator | Liu, Yanhong Huang, Lvzhen Wang, Zhiren Chen, Jingxu bian, Qingtao Sun, Jianyong Jiang, Liyan Yang, Fude |
| description | This study examined the changes in the retinal nerve fiber layer (RNFL) thickness and the macular thickness in Chinese patients with alcohol dependency and ascertaining the influence of optic cup volume on cognitive functioning.
A total of 26 alcohol-dependent patients and 53 age- and gender-matched healthy controls were enrolled in the study. All subjects underwent Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) measurement and were scanned via spectral-domain optical coherence tomography (OCT).
Compared with the healthy controls, the alcohol-dependent patients returned lower scores across all subscales and total RBANS scores. The total thickness of the RNFL of the left eye, temporal and nasal RNFLthickness of both eyes were thinner in the alcohol-dependent patients (all p |
| doi_str_mv | 10.1016/j.drugalcdep.2021.109130 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2597491965</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0376871621006256</els_id><sourcerecordid>2623043329</sourcerecordid><originalsourceid>FETCH-LOGICAL-c402t-4716106c4b6ebd1aaff12b48e38d8b768553a2e19638f09ff787e899ab8f0df83</originalsourceid><addsrcrecordid>eNqFkUtv1DAUhS0EotPCX0CW2LDJYMcZP5Yw4lGpEpuythz7unHIOIOdFM2_55YpILHBC7_0Hd_jewihnG054_LtuA1lvXOTD3DctqzleG24YE_IhmtlGsY6-ZRsmFCy0YrLC3JZ68hwSMOekwvRKSWUkhsy3g5A_eDyHVSaMi2wpOwmmqHcA42ph0Ind8LZ5UAPzq-TK3QZkv-Wof6S7IeEW6BHtyTIS6U_0jJQNDcP80TRIeQA2Z9ekGfRTRVePq5X5OvHD7f7z83Nl0_X-3c3je9YuzQd-uVM-q6X0AfuXIy87TsNQgfdK6l3O-Fa4EYKHZmJUWkF2hjX4zFELa7Im_O7xzJ_X6Eu9pCqh2lyGea12nZnVGdQv0P09T_oOK8F_4-UbAXrhGgNUvpM-TLXWiDaY0kHV06WM_uQhx3t3zzsQx72nAdKXz0WWPsDhD_C3wEg8P4MAHbkPkGx1WMXPYRUwC82zOn_VX4CeQihSQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2623043329</pqid></control><display><type>article</type><title>The changes in retinal nerve fiber layer and macular thickness in Chinese patients with alcohol dependency</title><source>Applied Social Sciences Index & Abstracts (ASSIA)</source><source>ScienceDirect Journals</source><source>ScienceDirect database</source><creator>Liu, Yanhong ; Huang, Lvzhen ; Wang, Zhiren ; Chen, Jingxu ; bian, Qingtao ; Sun, Jianyong ; Jiang, Liyan ; Yang, Fude</creator><creatorcontrib>Liu, Yanhong ; Huang, Lvzhen ; Wang, Zhiren ; Chen, Jingxu ; bian, Qingtao ; Sun, Jianyong ; Jiang, Liyan ; Yang, Fude</creatorcontrib><description>This study examined the changes in the retinal nerve fiber layer (RNFL) thickness and the macular thickness in Chinese patients with alcohol dependency and ascertaining the influence of optic cup volume on cognitive functioning.
A total of 26 alcohol-dependent patients and 53 age- and gender-matched healthy controls were enrolled in the study. All subjects underwent Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) measurement and were scanned via spectral-domain optical coherence tomography (OCT).
Compared with the healthy controls, the alcohol-dependent patients returned lower scores across all subscales and total RBANS scores. The total thickness of the RNFL of the left eye, temporal and nasal RNFLthickness of both eyes were thinner in the alcohol-dependent patients (all p < 0.05). In terms of macular thickness, eight macular regions and the average thickness of the right eye and three of the left eye were thinner in the alcohol-dependent patients than in the healthy controls. The linear regression analysis indicated that a higher alcohol consumption was associated with thinner RNFL and macular thickness especially in temporal and inferior quadrant region after controlling for smoker status, age, BMI, cholesterol level and AKT level.
A higher alcohol consumption was significantly associated with thinner RNFL and macular thickness, indicating that alcohol is a potential risk factor affecting RNFL thickness and macular thickness. Meanwhile, the increase in optic cup volume was associated with the reduced cognitive functioning of the alcohol-dependent patients.
•It is found with the relationship between neurocognition involved in visual participation and retinal nerve fibers.•The abnormal structures of retinal nerve fibers and macular thickness in patients with alcoholic dependence were found.•The possible mechanism of cognitive impairment caused by abnormal retinal nerve of alcoholic dependence was proposed.</description><identifier>ISSN: 0376-8716</identifier><identifier>EISSN: 1879-0046</identifier><identifier>DOI: 10.1016/j.drugalcdep.2021.109130</identifier><identifier>PMID: 34773776</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>AKT protein ; Alcohol dependence ; Alcohol use ; Alcoholism ; Alcoholism - diagnostic imaging ; Alcohols ; Body mass index ; China - epidemiology ; Cholesterol ; Cognitive ability ; Cognitive functioning ; Coherence ; Dependence ; Dependency ; Eye ; Eye (anatomy) ; Humans ; Macular thickness ; Measurement ; Nerve Fibers ; Optical coherence tomography ; Regression analysis ; Retina ; Retinal Ganglion Cells ; Retinal nerve fiber layer ; Risk analysis ; Risk factors ; Smoking ; Thickness ; Tomography ; Tomography, Optical Coherence</subject><ispartof>Drug and alcohol dependence, 2021-12, Vol.229 (Pt B), p.109130-109130, Article 109130</ispartof><rights>2021 Elsevier B.V.</rights><rights>Copyright © 2021 Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier Science Ltd. Dec 1, 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-4716106c4b6ebd1aaff12b48e38d8b768553a2e19638f09ff787e899ab8f0df83</citedby><cites>FETCH-LOGICAL-c402t-4716106c4b6ebd1aaff12b48e38d8b768553a2e19638f09ff787e899ab8f0df83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0376871621006256$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27924,27925,30999,45780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34773776$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Yanhong</creatorcontrib><creatorcontrib>Huang, Lvzhen</creatorcontrib><creatorcontrib>Wang, Zhiren</creatorcontrib><creatorcontrib>Chen, Jingxu</creatorcontrib><creatorcontrib>bian, Qingtao</creatorcontrib><creatorcontrib>Sun, Jianyong</creatorcontrib><creatorcontrib>Jiang, Liyan</creatorcontrib><creatorcontrib>Yang, Fude</creatorcontrib><title>The changes in retinal nerve fiber layer and macular thickness in Chinese patients with alcohol dependency</title><title>Drug and alcohol dependence</title><addtitle>Drug Alcohol Depend</addtitle><description>This study examined the changes in the retinal nerve fiber layer (RNFL) thickness and the macular thickness in Chinese patients with alcohol dependency and ascertaining the influence of optic cup volume on cognitive functioning.
A total of 26 alcohol-dependent patients and 53 age- and gender-matched healthy controls were enrolled in the study. All subjects underwent Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) measurement and were scanned via spectral-domain optical coherence tomography (OCT).
Compared with the healthy controls, the alcohol-dependent patients returned lower scores across all subscales and total RBANS scores. The total thickness of the RNFL of the left eye, temporal and nasal RNFLthickness of both eyes were thinner in the alcohol-dependent patients (all p < 0.05). In terms of macular thickness, eight macular regions and the average thickness of the right eye and three of the left eye were thinner in the alcohol-dependent patients than in the healthy controls. The linear regression analysis indicated that a higher alcohol consumption was associated with thinner RNFL and macular thickness especially in temporal and inferior quadrant region after controlling for smoker status, age, BMI, cholesterol level and AKT level.
A higher alcohol consumption was significantly associated with thinner RNFL and macular thickness, indicating that alcohol is a potential risk factor affecting RNFL thickness and macular thickness. Meanwhile, the increase in optic cup volume was associated with the reduced cognitive functioning of the alcohol-dependent patients.
•It is found with the relationship between neurocognition involved in visual participation and retinal nerve fibers.•The abnormal structures of retinal nerve fibers and macular thickness in patients with alcoholic dependence were found.•The possible mechanism of cognitive impairment caused by abnormal retinal nerve of alcoholic dependence was proposed.</description><subject>AKT protein</subject><subject>Alcohol dependence</subject><subject>Alcohol use</subject><subject>Alcoholism</subject><subject>Alcoholism - diagnostic imaging</subject><subject>Alcohols</subject><subject>Body mass index</subject><subject>China - epidemiology</subject><subject>Cholesterol</subject><subject>Cognitive ability</subject><subject>Cognitive functioning</subject><subject>Coherence</subject><subject>Dependence</subject><subject>Dependency</subject><subject>Eye</subject><subject>Eye (anatomy)</subject><subject>Humans</subject><subject>Macular thickness</subject><subject>Measurement</subject><subject>Nerve Fibers</subject><subject>Optical coherence tomography</subject><subject>Regression analysis</subject><subject>Retina</subject><subject>Retinal Ganglion Cells</subject><subject>Retinal nerve fiber layer</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Smoking</subject><subject>Thickness</subject><subject>Tomography</subject><subject>Tomography, Optical Coherence</subject><issn>0376-8716</issn><issn>1879-0046</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>7QJ</sourceid><recordid>eNqFkUtv1DAUhS0EotPCX0CW2LDJYMcZP5Yw4lGpEpuythz7unHIOIOdFM2_55YpILHBC7_0Hd_jewihnG054_LtuA1lvXOTD3DctqzleG24YE_IhmtlGsY6-ZRsmFCy0YrLC3JZ68hwSMOekwvRKSWUkhsy3g5A_eDyHVSaMi2wpOwmmqHcA42ph0Ind8LZ5UAPzq-TK3QZkv-Wof6S7IeEW6BHtyTIS6U_0jJQNDcP80TRIeQA2Z9ekGfRTRVePq5X5OvHD7f7z83Nl0_X-3c3je9YuzQd-uVM-q6X0AfuXIy87TsNQgfdK6l3O-Fa4EYKHZmJUWkF2hjX4zFELa7Im_O7xzJ_X6Eu9pCqh2lyGea12nZnVGdQv0P09T_oOK8F_4-UbAXrhGgNUvpM-TLXWiDaY0kHV06WM_uQhx3t3zzsQx72nAdKXz0WWPsDhD_C3wEg8P4MAHbkPkGx1WMXPYRUwC82zOn_VX4CeQihSQ</recordid><startdate>20211201</startdate><enddate>20211201</enddate><creator>Liu, Yanhong</creator><creator>Huang, Lvzhen</creator><creator>Wang, Zhiren</creator><creator>Chen, Jingxu</creator><creator>bian, Qingtao</creator><creator>Sun, Jianyong</creator><creator>Jiang, Liyan</creator><creator>Yang, Fude</creator><general>Elsevier B.V</general><general>Elsevier Science Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20211201</creationdate><title>The changes in retinal nerve fiber layer and macular thickness in Chinese patients with alcohol dependency</title><author>Liu, Yanhong ; Huang, Lvzhen ; Wang, Zhiren ; Chen, Jingxu ; bian, Qingtao ; Sun, Jianyong ; Jiang, Liyan ; Yang, Fude</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-4716106c4b6ebd1aaff12b48e38d8b768553a2e19638f09ff787e899ab8f0df83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>AKT protein</topic><topic>Alcohol dependence</topic><topic>Alcohol use</topic><topic>Alcoholism</topic><topic>Alcoholism - diagnostic imaging</topic><topic>Alcohols</topic><topic>Body mass index</topic><topic>China - epidemiology</topic><topic>Cholesterol</topic><topic>Cognitive ability</topic><topic>Cognitive functioning</topic><topic>Coherence</topic><topic>Dependence</topic><topic>Dependency</topic><topic>Eye</topic><topic>Eye (anatomy)</topic><topic>Humans</topic><topic>Macular thickness</topic><topic>Measurement</topic><topic>Nerve Fibers</topic><topic>Optical coherence tomography</topic><topic>Regression analysis</topic><topic>Retina</topic><topic>Retinal Ganglion Cells</topic><topic>Retinal nerve fiber layer</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Smoking</topic><topic>Thickness</topic><topic>Tomography</topic><topic>Tomography, Optical Coherence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Yanhong</creatorcontrib><creatorcontrib>Huang, Lvzhen</creatorcontrib><creatorcontrib>Wang, Zhiren</creatorcontrib><creatorcontrib>Chen, Jingxu</creatorcontrib><creatorcontrib>bian, Qingtao</creatorcontrib><creatorcontrib>Sun, Jianyong</creatorcontrib><creatorcontrib>Jiang, Liyan</creatorcontrib><creatorcontrib>Yang, Fude</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Drug and alcohol dependence</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Yanhong</au><au>Huang, Lvzhen</au><au>Wang, Zhiren</au><au>Chen, Jingxu</au><au>bian, Qingtao</au><au>Sun, Jianyong</au><au>Jiang, Liyan</au><au>Yang, Fude</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The changes in retinal nerve fiber layer and macular thickness in Chinese patients with alcohol dependency</atitle><jtitle>Drug and alcohol dependence</jtitle><addtitle>Drug Alcohol Depend</addtitle><date>2021-12-01</date><risdate>2021</risdate><volume>229</volume><issue>Pt B</issue><spage>109130</spage><epage>109130</epage><pages>109130-109130</pages><artnum>109130</artnum><issn>0376-8716</issn><eissn>1879-0046</eissn><abstract>This study examined the changes in the retinal nerve fiber layer (RNFL) thickness and the macular thickness in Chinese patients with alcohol dependency and ascertaining the influence of optic cup volume on cognitive functioning.
A total of 26 alcohol-dependent patients and 53 age- and gender-matched healthy controls were enrolled in the study. All subjects underwent Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) measurement and were scanned via spectral-domain optical coherence tomography (OCT).
Compared with the healthy controls, the alcohol-dependent patients returned lower scores across all subscales and total RBANS scores. The total thickness of the RNFL of the left eye, temporal and nasal RNFLthickness of both eyes were thinner in the alcohol-dependent patients (all p < 0.05). In terms of macular thickness, eight macular regions and the average thickness of the right eye and three of the left eye were thinner in the alcohol-dependent patients than in the healthy controls. The linear regression analysis indicated that a higher alcohol consumption was associated with thinner RNFL and macular thickness especially in temporal and inferior quadrant region after controlling for smoker status, age, BMI, cholesterol level and AKT level.
A higher alcohol consumption was significantly associated with thinner RNFL and macular thickness, indicating that alcohol is a potential risk factor affecting RNFL thickness and macular thickness. Meanwhile, the increase in optic cup volume was associated with the reduced cognitive functioning of the alcohol-dependent patients.
•It is found with the relationship between neurocognition involved in visual participation and retinal nerve fibers.•The abnormal structures of retinal nerve fibers and macular thickness in patients with alcoholic dependence were found.•The possible mechanism of cognitive impairment caused by abnormal retinal nerve of alcoholic dependence was proposed.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>34773776</pmid><doi>10.1016/j.drugalcdep.2021.109130</doi><tpages>1</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0376-8716 |
| ispartof | Drug and alcohol dependence, 2021-12, Vol.229 (Pt B), p.109130-109130, Article 109130 |
| issn | 0376-8716 1879-0046 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2597491965 |
| source | Applied Social Sciences Index & Abstracts (ASSIA); ScienceDirect Journals; ScienceDirect database |
| subjects | AKT protein Alcohol dependence Alcohol use Alcoholism Alcoholism - diagnostic imaging Alcohols Body mass index China - epidemiology Cholesterol Cognitive ability Cognitive functioning Coherence Dependence Dependency Eye Eye (anatomy) Humans Macular thickness Measurement Nerve Fibers Optical coherence tomography Regression analysis Retina Retinal Ganglion Cells Retinal nerve fiber layer Risk analysis Risk factors Smoking Thickness Tomography Tomography, Optical Coherence |
| title | The changes in retinal nerve fiber layer and macular thickness in Chinese patients with alcohol dependency |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T17%3A38%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20changes%20in%20retinal%20nerve%20fiber%20layer%20and%20macular%20thickness%20in%20Chinese%20patients%20with%20alcohol%20dependency&rft.jtitle=Drug%20and%20alcohol%20dependence&rft.au=Liu,%20Yanhong&rft.date=2021-12-01&rft.volume=229&rft.issue=Pt%20B&rft.spage=109130&rft.epage=109130&rft.pages=109130-109130&rft.artnum=109130&rft.issn=0376-8716&rft.eissn=1879-0046&rft_id=info:doi/10.1016/j.drugalcdep.2021.109130&rft_dat=%3Cproquest_cross%3E2623043329%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c402t-4716106c4b6ebd1aaff12b48e38d8b768553a2e19638f09ff787e899ab8f0df83%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2623043329&rft_id=info:pmid/34773776&rfr_iscdi=true |