Fibroblast Growth Factor 23 Level and Cardiovascular Parameters in Children with Chronic Kidney Disease

Objective To find out the serum fibroblast growth factor 23 (FGF-23) levels in different grades of CKD, and the prevalence of abnormal left ventricular mass index (LVMI), carotid intima–medial thickness (cIMT), and central pulse wave velocity (cPWV) and the risk factors including FGF-23 for these ab...

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Bibliographic Details
Published in:Indian journal of pediatrics 2022-09, Vol.89 (9), p.865-871
Main Authors: Singh, Gaurav, Mishra, Om P., Abhinay, Abhishek, Agarwal, Vikas, Mishra, Surendra P., Dwivedi, Amitnandan D., Singh, Ankur, Prasad, Rajniti, Mishra, Rabindra N.
Format: Article
Language:English
Subjects:
Gynecology
Medicine
Medicine & Public Health
Original Article
Pediatrics
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Summary:Objective To find out the serum fibroblast growth factor 23 (FGF-23) levels in different grades of CKD, and the prevalence of abnormal left ventricular mass index (LVMI), carotid intima–medial thickness (cIMT), and central pulse wave velocity (cPWV) and the risk factors including FGF-23 for these abnormalities. Methods Fifty-nine patients of CKD with G2 to G5, aged 2–18 y were included. The LVMI, cIMT, and cPWV were measured using standard techniques, and serum intact FGF-23 levels were estimated at enrollment. Results Median FGF-23 levels were significantly raised in all the grades of CKD than controls ( p  
ISSN:0019-5456
0973-7693
DOI:10.1007/s12098-021-03927-x