Underutilization of advanced presurgical studies and high rates of vagus nerve stimulation for drug-resistant epilepsy: a single-center experience and recommendations

• Published in: Acta neurochirurgica 2022-02, Vol.164 (2), p.565-573
• Main Authors: Solli, Elena, Colwell, Nicole A., Markosian, Christopher, Johal, Anmol S., Houston, Rebecca, Iqbal, M. Omar, Say, Irene, Petrsoric, Joseph I., Tomycz, Luke D.
• Format: Article
• Language: English
• Subjects: Brain mapping; Child; Computed tomography; Diagnosis; Drug resistance; Drug Resistant Epilepsy - diagnostic imaging; Drug Resistant Epilepsy - surgery; EEG; Electroencephalography - methods; Epilepsy; Epilepsy - diagnostic imaging; Epilepsy - surgery; Functional magnetic resonance imaging; Humans; Interventional Radiology; Magnetic Resonance Imaging; Magnetoencephalography; Medicine; Medicine & Public Health; Minimally Invasive Surgery; Neuroimaging; Neurology; Neuroradiology; Neurosurgery; Neurosurgery general; Original Article - Neurosurgery general; Patients; Pediatrics; Positron emission tomography; Retrospective Studies; Single photon emission computed tomography; Surgery; Surgical Orthopedics; Tomography; Tomography, Emission-Computed, Single-Photon; Treatment Outcome; Vagus nerve; Vagus Nerve Stimulation
• ISSN: 0001-6268; 0942-0940
• DOI: 10.1007/s00701-021-05055-z

Introduction Epilepsy surgery continues to be profoundly underutilized despite its safety and effectiveness. We sought to investigate factors that may contribute to this phenomenon, with a particular focus on the antecedent underutilization of appropriate preoperative studies. Methods We reviewed patient data from a pediatric epilepsy clinic over an 18-month period. Patients with drug-resistant epilepsy (DRE) were categorized according to brain magnetic resonance imaging (MRI) findings (lesional, MRI-negative, or multifocal abnormalities) and type of epilepsy diagnosis based on semiology and electroencephalography (EEG) (focal or generalized). We then analyzed the rates of diagnostic test utilization, surgical referral, and subsequent epilepsy surgery as well as vagus nerve stimulation (VNS). Results Of the 249 patients with a diagnosis of epilepsy, 138 (55.4%) were found to have DRE. Excluding the 10 patients with DRE who did not undergo MRI, 76 patients (59.4%) were found to be MRI-negative (non-lesional epilepsy), 37 patients (28.9%) were found to have multifocal abnormalities, and 15 patients (11.7%) were found to have a single epileptogenic lesion on MRI (lesional epilepsy). Positron emission tomography (PET) and single-photon emission computed tomography (SPECT) were each completed in nine patients (7.0%) and magnetoencephalography (MEG) in four patients (3.1%). Despite the low utilization rate of adjunctive studies, over half (56.3%) ultimately underwent VNS alone, and 8.6% ultimately underwent definitive intracranial resection or disconnection surgery. Conclusions The underutilization of appropriate non-invasive, presurgical testing in patients with focal DRE may in part explain the continued underutilization of definitive, resective/disconnective surgery. For patients without access to a high-volume, multidisciplinary surgical epilepsy center, adjunctive presurgical studies [e.g., PET, SPECT, MEG, electrical source imaging (ESI), EEG-functional magnetic resonance imaging (fMRI)], even when available, are rarely ordered, and this may contribute to excessive rates of VNS in lieu of definitive intracranial surgery.