Chronic wound healing by controlled release of chitosan hydrogels loaded with silver nanoparticles and calendula extract

As the skin is the main protective organ of the body, it is exposed to wounds or injuries which carry out a healing process during a period of approximately 15 days depending on the severity of the injury. In the present research, the development of chitosan-based hydrogels loaded with silver nanopa...

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Bibliographic Details
Published in:Journal of tissue viability 2022-02, Vol.31 (1), p.173-179
Main Authors: Rodríguez-Acosta, Hugo, Tapia- Rivera, José M., Guerrero-Guzmán, Andrea, Hernández-Elizarraráz, Erika, Hernández- Díaz, José A., Garza- García, Jorge J.O., Pérez- Ramírez, Pablo E., Velasco- Ramírez, Sandra F., Ramírez- Anguiano, Ana C., Velázquez- Juárez, Gilberto, Velázquez- López, José M., Sánchez- Toscano, Yadira G., García- Morales, Soledad, Flores-Fonseca, Milagros M., García- Bustos, David E., Sánchez- Chiprés, David R., Zamudio- Ojeda, Adalberto
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Calendula
Chitosan - pharmacology
Clinical case
Delayed-Action Preparations
Diabetes
Escherichia coli
Humans
Hydrogels - pharmacology
Injurie
Metal Nanoparticles
Nanoparticles
Plant Extracts
Silver - pharmacology
Staphylococcus aureus
Wound
Wound Healing
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Summary:As the skin is the main protective organ of the body, it is exposed to wounds or injuries which carry out a healing process during a period of approximately 15 days depending on the severity of the injury. In the present research, the development of chitosan-based hydrogels loaded with silver nanoparticles and calendula extract (Ch-AgNPs-Ce) was proposed. This can be used to fulfill the hemostatic, anti-infective, antibacterial, healing and anti-inflammatory functions through controlled release of the nanoparticles and calendula extract in substitution of commonly used drugs. The physical properties of the silver nanoparticles were analyzed by UV–visible spectroscopy, scanning and transmission electron microscopy, showing a size between 50 and 100 nm. The antibacterial properties were evaluated by the agar well diffusion method. Antimicrobial testing of the hydrogels showed that the inclusion of silver nanoparticles provides concentration-dependent antibacterial behavior against E. coli and S. aureus. The healing properties of the system were tested in two diabetic patients to whom said hydrogels were placed, obtaining a positive curative result after a few weeks. Therefore, it can be concluded that Ch-AgNPs-Ce hydrogels can achieve healing in chronic or exposed wounds after a period of time which can be used in alternative treatments in patients with poor healing capacity.
ISSN:0965-206X
DOI:10.1016/j.jtv.2021.10.004