Control of cell signaling by Arf GTPases and their regulators: Focus on links to cancer and other GTPase families

• Published in: Biochimica et biophysica acta. Molecular cell research 2022-02, Vol.1869 (2), p.119171-119171, Article 119171
• Main Authors: Chen, Pei-Wen, Gasilina, Anjelika, Yadav, Mukesh P., Randazzo, Paul A.
• Format: Article
• Language: English
• Subjects: ADP-Ribosylation factor; ADP-Ribosylation Factor 1 - metabolism; ADP-Ribosylation Factor 6 - metabolism; Animals; Arf; Gene Expression Regulation, Neoplastic; GTP Phosphohydrolases - metabolism; Humans; Membrane traffic; Neoplasms - metabolism; Neoplasms - pathology; Signaling
• ISSN: 0167-4889; 1879-2596
• DOI: 10.1016/j.bbamcr.2021.119171

The ADP-ribosylation factors (Arfs) comprise a family of regulatory GTP binding proteins. The Arfs regulate membrane trafficking and cytoskeleton remodeling, processes critical for eukaryotes and which have been the focus of most studies on Arfs. A more limited literature describes a role in signaling and in integrating several signaling pathways to bring about specific cell behaviors. Here, we will highlight work describing function of Arf1, Arf6 and several effectors and regulators of Arfs in signaling. •Arf GTPases and their regulators affect signaling pathways by diverse mechanisms.•Arf6 affects lifetime of endocytic vesicles that support signaling.•Arf1 and Arf6 regulates synthesis of signaling lipids by three mechanisms.•Arf1 and Arf6 can directly bind to regulators of other GTPase families.•Arf GEFs and GAPs affect signals by regulating Arfs and by binding signaling proteins.