Systematic interaction of plasma albumin with the efficacy of chemotherapeutic drugs

Albumin, as the most abundant plasma protein, plays an integral role in the transport of a variety of exogenous and endogenous ligands in the bloodstream and extravascular spaces. For exogenous drugs, especially chemotherapeutic drugs, binding to and being delivered by albumin can significantly affe...

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Bibliographic Details
Published in:Biochimica et biophysica acta. Reviews on cancer 2022-01, Vol.1877 (1), p.188655-188655, Article 188655
Main Authors: Yu, Liuchunyang, Hua, Zhenglai, Luo, Xinyi, Zhao, Ting, Liu, Yuanyan
Format: Article
Language:English
Subjects:
Albumin
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Chemotherapeutic drugs
Drug carrier
Drug efficacy
Fatty acids
Fatty Acids - metabolism
Humans
Ligands
Neoplasms - drug therapy
Protein Binding
Serum Albumin - chemistry
Serum Albumin - metabolism
Tumor accumulation
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Summary:Albumin, as the most abundant plasma protein, plays an integral role in the transport of a variety of exogenous and endogenous ligands in the bloodstream and extravascular spaces. For exogenous drugs, especially chemotherapeutic drugs, binding to and being delivered by albumin can significantly affect their efficacy. Meanwhile, albumin can also bind to many endogenous ligands, such as fatty acids, with important physiological significance that can affect tumor proliferation and metabolism. In this review, we summarize how albumin with unique properties affects chemotherapeutic drugs efficacy from the aspects of drug outcome in blood, toxicity, tumor accumulation and direct or indirect interactions with fatty acids, plus application of albumin-based carriers for anti-tumor drug delivery.
ISSN:0304-419X
1879-2561
DOI:10.1016/j.bbcan.2021.188655