A potential role of fibrillin-1 (FBN1) mRNA and asprosin in follicular development in water buffalo

Fibrillin-1 (FBN1) functions as a structural protein in the ovary, while the role of its protein product asprosin remains unknown. Both proteins are encoded by the FBN1 gene and when it is cleaved at the C-terminal end, asprosin is produced. Asprosin is associated with various metabolic parameters a...

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Bibliographic Details
Published in:Theriogenology 2022-01, Vol.178, p.67-72
Main Authors: Maylem, Excel Rio S., Spicer, Leon J., Atabay, Eufrocina P., Atabay, Edwin C., Batalha, Isadora, Schutz, Luis F.
Format: Article
Language:English
Subjects:
Animals
Asprosin
Buffaloes
Cattle
Estradiol
Female
Fibrillin-1
Fibrillin-1 - genetics
Follicular Fluid
Gene Expression Regulation
Granulosa Cells
RNA, Messenger - genetics
Water buffalo
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Summary:Fibrillin-1 (FBN1) functions as a structural protein in the ovary, while the role of its protein product asprosin remains unknown. Both proteins are encoded by the FBN1 gene and when it is cleaved at the C-terminal end, asprosin is produced. Asprosin is associated with various metabolic parameters and sex-related hormones in women. One goal of this research was to quantify FBN1 and the presumed asprosin receptor, olfactory receptor family 4 subfamily M member 1 (OR4M1) mRNA in water buffalo granulosa cells and correlate them to aromatase (CYP19A1) gene expression. A second goal was to determine the effect of asprosin on follicular growth in vivo. In Exp. 1, ovaries were collected from a local slaughterhouse, follicular fluid and granulosa cells from small (
ISSN:0093-691X
1879-3231
DOI:10.1016/j.theriogenology.2021.11.004