Male Age and Progressive Sperm Motility Are Critical Factors Affecting Embryological and Clinical Outcomes in Oocyte Donor ICSI Cycles

This retrospective cohort study aimed to explore whether paternal age and semen quality parameters affect the embryological and clinical outcomes of ICSI with oocyte donation. A total of 339 oocyte donation (OD)-ICSI cycles were categorized into four groups according to the semen parameter profiles...

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Bibliographic Details
Published in:Reproductive sciences (Thousand Oaks, Calif.) Calif.), 2022-03, Vol.29 (3), p.883-895
Main Authors: Vogiatzi, Paraskevi, Pouliakis, Abraham, Sakellariou, Maria, Athanasiou, Aikaterini, Athanasiou, Adamantios, Colaghis, Alexandros, Finelli, Renata, Loutradis, Dimitrios, Henkel, Ralf, Agarwal, Ashok
Format: Article
Language:English
Subjects:
Adult
Age Factors
Embryology
Female
Humans
Male
Male Reproduction: Original Article
Medicine
Medicine & Public Health
Middle Aged
Obstetrics/Perinatology/Midwifery
Oocyte Donation
Pregnancy
Pregnancy Rate
Reproductive Medicine
Retrospective Studies
Sperm Injections, Intracytoplasmic
Sperm Motility
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Summary:This retrospective cohort study aimed to explore whether paternal age and semen quality parameters affect the embryological and clinical outcomes of ICSI with oocyte donation. A total of 339 oocyte donation (OD)-ICSI cycles were categorized into four groups according to the semen parameter profiles of the male counterparts: normozoospermia (NS, n  = 184), oligozoospermia (OS, n  = 41), asthenozoospermia (AS, n  = 50), and oligoasthenozoospermia (OAS, n  = 64). The effect of age, total sperm count, and progressive motility was separately analyzed for reproductive outcomes and compared between the study groups: fertilization, blastulation, and top-quality embryo rate, biochemical and clinical pregnancy, live birth, and miscarriage. A negative correlation between male age and fertilization rate was observed ( r s  =  − 0.23, p  
ISSN:1933-7191
1933-7205
DOI:10.1007/s43032-021-00801-1