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Male Age and Progressive Sperm Motility Are Critical Factors Affecting Embryological and Clinical Outcomes in Oocyte Donor ICSI Cycles
This retrospective cohort study aimed to explore whether paternal age and semen quality parameters affect the embryological and clinical outcomes of ICSI with oocyte donation. A total of 339 oocyte donation (OD)-ICSI cycles were categorized into four groups according to the semen parameter profiles...
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| Published in: | Reproductive sciences (Thousand Oaks, Calif.) Calif.), 2022-03, Vol.29 (3), p.883-895 |
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| container_title | Reproductive sciences (Thousand Oaks, Calif.) |
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| creator | Vogiatzi, Paraskevi Pouliakis, Abraham Sakellariou, Maria Athanasiou, Aikaterini Athanasiou, Adamantios Colaghis, Alexandros Finelli, Renata Loutradis, Dimitrios Henkel, Ralf Agarwal, Ashok |
| description | This retrospective cohort study aimed to explore whether paternal age and semen quality parameters affect the embryological and clinical outcomes of ICSI with oocyte donation. A total of 339 oocyte donation (OD)-ICSI cycles were categorized into four groups according to the semen parameter profiles of the male counterparts: normozoospermia (NS,
n
= 184), oligozoospermia (OS,
n
= 41), asthenozoospermia (AS,
n
= 50), and oligoasthenozoospermia (OAS,
n
= 64). The effect of age, total sperm count, and progressive motility was separately analyzed for reproductive outcomes and compared between the study groups: fertilization, blastulation, and top-quality embryo rate, biochemical and clinical pregnancy, live birth, and miscarriage. A negative correlation between male age and fertilization rate was observed (
r
s
= − 0.23,
p
|
| doi_str_mv | 10.1007/s43032-021-00801-1 |
| format | article |
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n
= 184), oligozoospermia (OS,
n
= 41), asthenozoospermia (AS,
n
= 50), and oligoasthenozoospermia (OAS,
n
= 64). The effect of age, total sperm count, and progressive motility was separately analyzed for reproductive outcomes and compared between the study groups: fertilization, blastulation, and top-quality embryo rate, biochemical and clinical pregnancy, live birth, and miscarriage. A negative correlation between male age and fertilization rate was observed (
r
s
= − 0.23,
p
< 0.0001), while male age was a significant factor for biochemical pregnancy (
p
= 0.0002), clinical pregnancy (
p
= 0.0017), and live birth (
p
= 0.0038). Reduced total sperm count and lowered progressive motility led to poorer fertilization rates (
r
s
= 0.19 and 0.35, respectively,
p
< 0.0001) and affected embryo quality (
r
s
= 0.13,
p
= 0.02, and
r
s
= 0.22,
p
< 0.0001, respectively). OD-ICSI cycles with asthenozoospermia had significantly lowered success rates in biochemical pregnancy, clinical pregnancy, and live birth (
p
< 0.05). Our study demonstrated that both advanced male age and reduced progressive motility of spermatozoa exert a significant negative influence on the outcome of assisted reproduction, even in controlled procedures with gamete selection and optimization such as in OD-ICSI. Improvement in treatment strategies and male fertility evaluation requires incorporation of such evidence to obtain better prognosis towards personalized management.</description><identifier>ISSN: 1933-7191</identifier><identifier>EISSN: 1933-7205</identifier><identifier>DOI: 10.1007/s43032-021-00801-1</identifier><identifier>PMID: 34782988</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Adult ; Age Factors ; Embryology ; Female ; Humans ; Male ; Male Reproduction: Original Article ; Medicine ; Medicine & Public Health ; Middle Aged ; Obstetrics/Perinatology/Midwifery ; Oocyte Donation ; Pregnancy ; Pregnancy Rate ; Reproductive Medicine ; Retrospective Studies ; Sperm Injections, Intracytoplasmic ; Sperm Motility</subject><ispartof>Reproductive sciences (Thousand Oaks, Calif.), 2022-03, Vol.29 (3), p.883-895</ispartof><rights>Society for Reproductive Investigation 2021</rights><rights>2021. Society for Reproductive Investigation.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-c5038ec6ae22df0fa0ebbed9f46b635c6d322521a857a15f67096872dd7bd2bf3</citedby><cites>FETCH-LOGICAL-c391t-c5038ec6ae22df0fa0ebbed9f46b635c6d322521a857a15f67096872dd7bd2bf3</cites><orcidid>0000-0003-0585-1026 ; 0000-0002-8686-594X ; 0000-0002-5926-6407 ; 0000-0002-0074-3619 ; 0000-0001-9971-1619 ; 0000-0003-1128-2982</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34782988$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vogiatzi, Paraskevi</creatorcontrib><creatorcontrib>Pouliakis, Abraham</creatorcontrib><creatorcontrib>Sakellariou, Maria</creatorcontrib><creatorcontrib>Athanasiou, Aikaterini</creatorcontrib><creatorcontrib>Athanasiou, Adamantios</creatorcontrib><creatorcontrib>Colaghis, Alexandros</creatorcontrib><creatorcontrib>Finelli, Renata</creatorcontrib><creatorcontrib>Loutradis, Dimitrios</creatorcontrib><creatorcontrib>Henkel, Ralf</creatorcontrib><creatorcontrib>Agarwal, Ashok</creatorcontrib><title>Male Age and Progressive Sperm Motility Are Critical Factors Affecting Embryological and Clinical Outcomes in Oocyte Donor ICSI Cycles</title><title>Reproductive sciences (Thousand Oaks, Calif.)</title><addtitle>Reprod. Sci</addtitle><addtitle>Reprod Sci</addtitle><description>This retrospective cohort study aimed to explore whether paternal age and semen quality parameters affect the embryological and clinical outcomes of ICSI with oocyte donation. A total of 339 oocyte donation (OD)-ICSI cycles were categorized into four groups according to the semen parameter profiles of the male counterparts: normozoospermia (NS,
n
= 184), oligozoospermia (OS,
n
= 41), asthenozoospermia (AS,
n
= 50), and oligoasthenozoospermia (OAS,
n
= 64). The effect of age, total sperm count, and progressive motility was separately analyzed for reproductive outcomes and compared between the study groups: fertilization, blastulation, and top-quality embryo rate, biochemical and clinical pregnancy, live birth, and miscarriage. A negative correlation between male age and fertilization rate was observed (
r
s
= − 0.23,
p
< 0.0001), while male age was a significant factor for biochemical pregnancy (
p
= 0.0002), clinical pregnancy (
p
= 0.0017), and live birth (
p
= 0.0038). Reduced total sperm count and lowered progressive motility led to poorer fertilization rates (
r
s
= 0.19 and 0.35, respectively,
p
< 0.0001) and affected embryo quality (
r
s
= 0.13,
p
= 0.02, and
r
s
= 0.22,
p
< 0.0001, respectively). OD-ICSI cycles with asthenozoospermia had significantly lowered success rates in biochemical pregnancy, clinical pregnancy, and live birth (
p
< 0.05). Our study demonstrated that both advanced male age and reduced progressive motility of spermatozoa exert a significant negative influence on the outcome of assisted reproduction, even in controlled procedures with gamete selection and optimization such as in OD-ICSI. Improvement in treatment strategies and male fertility evaluation requires incorporation of such evidence to obtain better prognosis towards personalized management.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Embryology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Male Reproduction: Original Article</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Obstetrics/Perinatology/Midwifery</subject><subject>Oocyte Donation</subject><subject>Pregnancy</subject><subject>Pregnancy Rate</subject><subject>Reproductive Medicine</subject><subject>Retrospective Studies</subject><subject>Sperm Injections, Intracytoplasmic</subject><subject>Sperm Motility</subject><issn>1933-7191</issn><issn>1933-7205</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kM1O3DAQxy1UBBR4gR4qH3tJ8ccmsY-rFOhKoEUCzpbjjCMjJ97aTqW8QJ-bsAs9cpoZ_T-k-SH0jZKflJD6Kq044awgjBaECEILeoTOqOS8qBkpv3zsVNJT9DWlF0LKlWTiBJ3yVS2YFOIM_bvXHvC6B6zHDj_E0EdIyf0F_LiDOOD7kJ13ecbrCLiJLjujPb7RJoeY8NpaMNmNPb4e2jgHH_q9_tbVeDfuj-2UTRggYTfibTBzBvwrjCHiTfO4wc1sPKQLdGy1T3D5Ps_R8831U_O7uNvebpr1XWG4pLkwJeECTKWBsc4Sqwm0LXTSrqq24qWpOs5YyagWZa1paauayErUrOvqtmOt5efox6F3F8OfCVJWg0sGvNcjhCkpVkpBallRtljZwWpiSCmCVbvoBh1nRYl6468O_NXCX-35K7qEvr_3T-0A3f_IB_DFwA-GtEhjD1G9hCmOy8-f1b4CezeRiw</recordid><startdate>20220301</startdate><enddate>20220301</enddate><creator>Vogiatzi, Paraskevi</creator><creator>Pouliakis, Abraham</creator><creator>Sakellariou, Maria</creator><creator>Athanasiou, Aikaterini</creator><creator>Athanasiou, Adamantios</creator><creator>Colaghis, Alexandros</creator><creator>Finelli, Renata</creator><creator>Loutradis, Dimitrios</creator><creator>Henkel, Ralf</creator><creator>Agarwal, Ashok</creator><general>Springer International Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0585-1026</orcidid><orcidid>https://orcid.org/0000-0002-8686-594X</orcidid><orcidid>https://orcid.org/0000-0002-5926-6407</orcidid><orcidid>https://orcid.org/0000-0002-0074-3619</orcidid><orcidid>https://orcid.org/0000-0001-9971-1619</orcidid><orcidid>https://orcid.org/0000-0003-1128-2982</orcidid></search><sort><creationdate>20220301</creationdate><title>Male Age and Progressive Sperm Motility Are Critical Factors Affecting Embryological and Clinical Outcomes in Oocyte Donor ICSI Cycles</title><author>Vogiatzi, Paraskevi ; Pouliakis, Abraham ; Sakellariou, Maria ; Athanasiou, Aikaterini ; Athanasiou, Adamantios ; Colaghis, Alexandros ; Finelli, Renata ; Loutradis, Dimitrios ; Henkel, Ralf ; Agarwal, Ashok</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-c5038ec6ae22df0fa0ebbed9f46b635c6d322521a857a15f67096872dd7bd2bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Embryology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Male Reproduction: Original Article</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Obstetrics/Perinatology/Midwifery</topic><topic>Oocyte Donation</topic><topic>Pregnancy</topic><topic>Pregnancy Rate</topic><topic>Reproductive Medicine</topic><topic>Retrospective Studies</topic><topic>Sperm Injections, Intracytoplasmic</topic><topic>Sperm Motility</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vogiatzi, Paraskevi</creatorcontrib><creatorcontrib>Pouliakis, Abraham</creatorcontrib><creatorcontrib>Sakellariou, Maria</creatorcontrib><creatorcontrib>Athanasiou, Aikaterini</creatorcontrib><creatorcontrib>Athanasiou, Adamantios</creatorcontrib><creatorcontrib>Colaghis, Alexandros</creatorcontrib><creatorcontrib>Finelli, Renata</creatorcontrib><creatorcontrib>Loutradis, Dimitrios</creatorcontrib><creatorcontrib>Henkel, Ralf</creatorcontrib><creatorcontrib>Agarwal, Ashok</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Reproductive sciences (Thousand Oaks, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vogiatzi, Paraskevi</au><au>Pouliakis, Abraham</au><au>Sakellariou, Maria</au><au>Athanasiou, Aikaterini</au><au>Athanasiou, Adamantios</au><au>Colaghis, Alexandros</au><au>Finelli, Renata</au><au>Loutradis, Dimitrios</au><au>Henkel, Ralf</au><au>Agarwal, Ashok</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Male Age and Progressive Sperm Motility Are Critical Factors Affecting Embryological and Clinical Outcomes in Oocyte Donor ICSI Cycles</atitle><jtitle>Reproductive sciences (Thousand Oaks, Calif.)</jtitle><stitle>Reprod. Sci</stitle><addtitle>Reprod Sci</addtitle><date>2022-03-01</date><risdate>2022</risdate><volume>29</volume><issue>3</issue><spage>883</spage><epage>895</epage><pages>883-895</pages><issn>1933-7191</issn><eissn>1933-7205</eissn><abstract>This retrospective cohort study aimed to explore whether paternal age and semen quality parameters affect the embryological and clinical outcomes of ICSI with oocyte donation. A total of 339 oocyte donation (OD)-ICSI cycles were categorized into four groups according to the semen parameter profiles of the male counterparts: normozoospermia (NS,
n
= 184), oligozoospermia (OS,
n
= 41), asthenozoospermia (AS,
n
= 50), and oligoasthenozoospermia (OAS,
n
= 64). The effect of age, total sperm count, and progressive motility was separately analyzed for reproductive outcomes and compared between the study groups: fertilization, blastulation, and top-quality embryo rate, biochemical and clinical pregnancy, live birth, and miscarriage. A negative correlation between male age and fertilization rate was observed (
r
s
= − 0.23,
p
< 0.0001), while male age was a significant factor for biochemical pregnancy (
p
= 0.0002), clinical pregnancy (
p
= 0.0017), and live birth (
p
= 0.0038). Reduced total sperm count and lowered progressive motility led to poorer fertilization rates (
r
s
= 0.19 and 0.35, respectively,
p
< 0.0001) and affected embryo quality (
r
s
= 0.13,
p
= 0.02, and
r
s
= 0.22,
p
< 0.0001, respectively). OD-ICSI cycles with asthenozoospermia had significantly lowered success rates in biochemical pregnancy, clinical pregnancy, and live birth (
p
< 0.05). Our study demonstrated that both advanced male age and reduced progressive motility of spermatozoa exert a significant negative influence on the outcome of assisted reproduction, even in controlled procedures with gamete selection and optimization such as in OD-ICSI. Improvement in treatment strategies and male fertility evaluation requires incorporation of such evidence to obtain better prognosis towards personalized management.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>34782988</pmid><doi>10.1007/s43032-021-00801-1</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0003-0585-1026</orcidid><orcidid>https://orcid.org/0000-0002-8686-594X</orcidid><orcidid>https://orcid.org/0000-0002-5926-6407</orcidid><orcidid>https://orcid.org/0000-0002-0074-3619</orcidid><orcidid>https://orcid.org/0000-0001-9971-1619</orcidid><orcidid>https://orcid.org/0000-0003-1128-2982</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Reproductive sciences (Thousand Oaks, Calif.), 2022-03, Vol.29 (3), p.883-895 |
| issn | 1933-7191 1933-7205 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2598079612 |
| source | Springer Link |
| subjects | Adult Age Factors Embryology Female Humans Male Male Reproduction: Original Article Medicine Medicine & Public Health Middle Aged Obstetrics/Perinatology/Midwifery Oocyte Donation Pregnancy Pregnancy Rate Reproductive Medicine Retrospective Studies Sperm Injections, Intracytoplasmic Sperm Motility |
| title | Male Age and Progressive Sperm Motility Are Critical Factors Affecting Embryological and Clinical Outcomes in Oocyte Donor ICSI Cycles |
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