Modular amphiphilic poly(aryl ether)-based supramolecular nanomicelles: an efficient endocytic drug carrier

A rationally designed amphiphilic poly(aryl ether)-based dendrimer self-assembles into nanomicelles and exhibits tunable morphology upon varying the hydrophilic chain length. The 30 nm-sized dendrimer nanomicelles successfully entrapped Doxorubicin, demonstrated the sustained release of Doxorubicin...

Full description

Saved in:
Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2021-11, Vol.57 (94), p.12695-12698
Main Authors: Kannan, Ramya, Datta, Ayan, Prabakaran, Palani, Prasad, Edamana, Muthuvijayan, Vignesh
Format: Article
Language:English
Subjects:
Animals
Antibiotics, Antineoplastic - chemistry
Antibiotics, Antineoplastic - pharmacology
Aromatic compounds
Cell Proliferation - drug effects
Cell Survival - drug effects
Doxorubicin
Doxorubicin - chemistry
Doxorubicin - pharmacology
Drug carriers
Drug Carriers - chemical synthesis
Drug Carriers - chemistry
Drug Screening Assays, Antitumor
Endocytosis - drug effects
Ethers - chemical synthesis
Ethers - chemistry
Humans
Macromolecular Substances - chemical synthesis
Macromolecular Substances - chemistry
MCF-7 Cells
Mice
Micelles
Molecular Structure
Morphology
Nanoparticles - chemistry
NIH 3T3 Cells
Polymers - chemical synthesis
Polymers - chemistry
Surface-Active Agents - chemical synthesis
Surface-Active Agents - chemistry
Sustained release
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A rationally designed amphiphilic poly(aryl ether)-based dendrimer self-assembles into nanomicelles and exhibits tunable morphology upon varying the hydrophilic chain length. The 30 nm-sized dendrimer nanomicelles successfully entrapped Doxorubicin, demonstrated the sustained release of Doxorubicin and can successfully penetrate cancer cells through caveolae-dependent endocytosis, compared to the free drug. A rationally designed amphiphilic poly(aryl ether)-based dendrimer self-assembles into nanomicelles and exhibits tunable morphology upon varying the hydrophilic chain length.
ISSN:1359-7345
1364-548X
DOI:10.1039/d1cc05652b