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Modular amphiphilic poly(aryl ether)-based supramolecular nanomicelles: an efficient endocytic drug carrier
A rationally designed amphiphilic poly(aryl ether)-based dendrimer self-assembles into nanomicelles and exhibits tunable morphology upon varying the hydrophilic chain length. The 30 nm-sized dendrimer nanomicelles successfully entrapped Doxorubicin, demonstrated the sustained release of Doxorubicin...
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| Published in: | Chemical communications (Cambridge, England) England), 2021-11, Vol.57 (94), p.12695-12698 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c337t-412875250c06bdddd598a0ed7d5148c12e22c192cbc18c40234772a18e1f05ad3 |
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| cites | cdi_FETCH-LOGICAL-c337t-412875250c06bdddd598a0ed7d5148c12e22c192cbc18c40234772a18e1f05ad3 |
| container_end_page | 12698 |
| container_issue | 94 |
| container_start_page | 12695 |
| container_title | Chemical communications (Cambridge, England) |
| container_volume | 57 |
| creator | Kannan, Ramya Datta, Ayan Prabakaran, Palani Prasad, Edamana Muthuvijayan, Vignesh |
| description | A rationally designed amphiphilic poly(aryl ether)-based dendrimer self-assembles into nanomicelles and exhibits tunable morphology upon varying the hydrophilic chain length. The 30 nm-sized dendrimer nanomicelles successfully entrapped Doxorubicin, demonstrated the sustained release of Doxorubicin and can successfully penetrate cancer cells through caveolae-dependent endocytosis, compared to the free drug.
A rationally designed amphiphilic poly(aryl ether)-based dendrimer self-assembles into nanomicelles and exhibits tunable morphology upon varying the hydrophilic chain length. |
| doi_str_mv | 10.1039/d1cc05652b |
| format | article |
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A rationally designed amphiphilic poly(aryl ether)-based dendrimer self-assembles into nanomicelles and exhibits tunable morphology upon varying the hydrophilic chain length.</description><subject>Animals</subject><subject>Antibiotics, Antineoplastic - chemistry</subject><subject>Antibiotics, Antineoplastic - pharmacology</subject><subject>Aromatic compounds</subject><subject>Cell Proliferation - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>Doxorubicin</subject><subject>Doxorubicin - chemistry</subject><subject>Doxorubicin - pharmacology</subject><subject>Drug carriers</subject><subject>Drug Carriers - chemical synthesis</subject><subject>Drug Carriers - chemistry</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Endocytosis - drug effects</subject><subject>Ethers - chemical synthesis</subject><subject>Ethers - chemistry</subject><subject>Humans</subject><subject>Macromolecular Substances - chemical synthesis</subject><subject>Macromolecular Substances - chemistry</subject><subject>MCF-7 Cells</subject><subject>Mice</subject><subject>Micelles</subject><subject>Molecular Structure</subject><subject>Morphology</subject><subject>Nanoparticles - chemistry</subject><subject>NIH 3T3 Cells</subject><subject>Polymers - chemical synthesis</subject><subject>Polymers - chemistry</subject><subject>Surface-Active Agents - chemical synthesis</subject><subject>Surface-Active Agents - chemistry</subject><subject>Sustained release</subject><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpdkU1LxDAQhoMorq5evCsFLypUk7RpU2-6foLiRcFbSSdTt9o2NWkP--_NfriCM4EM5JmXybyEHDB6zmiUXWgGQEUieLFBdliUxKGI5fvmvBZZmEaxGJFd5z6pDybkNhlFcSp5RpMd8vVs9FArG6imm1b-1BUEnalnJ8rO6gD7KdrTsFAOdeCGzqrG1AiLjla1pqkA6xrdZaDaAMuyggrbPsBWG5j1Xkrb4SMAZW2Fdo9slap2uL-6x-Tt7vZ18hA-vdw_Tq6eQoiitA9jxmUquKBAk0L7EJlUFHWqBYslMI6cA8s4FMAkxJT736RcMYmspELpaExOlrqdNd8Duj5vKjefU7VoBpdzL0h9ptKjx__QTzPY1k-X84RyLhMuhKfOlhRY45zFMu9s1fgF5YzmcwvyGzaZLCy49vDRSnIoGtRr9HfnHjhcAtbB-vXPw-gH7p6LXw</recordid><startdate>20211125</startdate><enddate>20211125</enddate><creator>Kannan, Ramya</creator><creator>Datta, Ayan</creator><creator>Prabakaran, Palani</creator><creator>Prasad, Edamana</creator><creator>Muthuvijayan, Vignesh</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4921-9073</orcidid><orcidid>https://orcid.org/0000-0003-4996-9675</orcidid><orcidid>https://orcid.org/0000-0001-5484-5250</orcidid><orcidid>https://orcid.org/0000-0002-6643-1407</orcidid></search><sort><creationdate>20211125</creationdate><title>Modular amphiphilic poly(aryl ether)-based supramolecular nanomicelles: an efficient endocytic drug carrier</title><author>Kannan, Ramya ; 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The 30 nm-sized dendrimer nanomicelles successfully entrapped Doxorubicin, demonstrated the sustained release of Doxorubicin and can successfully penetrate cancer cells through caveolae-dependent endocytosis, compared to the free drug.
A rationally designed amphiphilic poly(aryl ether)-based dendrimer self-assembles into nanomicelles and exhibits tunable morphology upon varying the hydrophilic chain length.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>34782906</pmid><doi>10.1039/d1cc05652b</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0003-4921-9073</orcidid><orcidid>https://orcid.org/0000-0003-4996-9675</orcidid><orcidid>https://orcid.org/0000-0001-5484-5250</orcidid><orcidid>https://orcid.org/0000-0002-6643-1407</orcidid></addata></record> |
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| ispartof | Chemical communications (Cambridge, England), 2021-11, Vol.57 (94), p.12695-12698 |
| issn | 1359-7345 1364-548X |
| language | eng |
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| source | Royal Society of Chemistry |
| subjects | Animals Antibiotics, Antineoplastic - chemistry Antibiotics, Antineoplastic - pharmacology Aromatic compounds Cell Proliferation - drug effects Cell Survival - drug effects Doxorubicin Doxorubicin - chemistry Doxorubicin - pharmacology Drug carriers Drug Carriers - chemical synthesis Drug Carriers - chemistry Drug Screening Assays, Antitumor Endocytosis - drug effects Ethers - chemical synthesis Ethers - chemistry Humans Macromolecular Substances - chemical synthesis Macromolecular Substances - chemistry MCF-7 Cells Mice Micelles Molecular Structure Morphology Nanoparticles - chemistry NIH 3T3 Cells Polymers - chemical synthesis Polymers - chemistry Surface-Active Agents - chemical synthesis Surface-Active Agents - chemistry Sustained release |
| title | Modular amphiphilic poly(aryl ether)-based supramolecular nanomicelles: an efficient endocytic drug carrier |
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