Experimental deep brain stimulation in rodent models of movement disorders

Deep brain stimulation (DBS) is the preferred treatment for therapy-resistant movement disorders such as dystonia and Parkinson's disease (PD), mostly in advanced disease stages. Although DBS is already in clinical use for ~30 years and has improved patients' quality of life dramatically,...

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Bibliographic Details
Published in:Experimental neurology 2022-02, Vol.348, p.113926-113926, Article 113926
Main Authors: Knorr, Susanne, Musacchio, Thomas, Paulat, Raik, Matthies, Cordula, Endres, Heinz, Wenger, Nikolaus, Harms, Christoph, Ip, Chi Wang
Format: Article
Language:English
Subjects:
Animals
Animals, Genetically Modified
Brain - metabolism
Brain - pathology
Brain-Derived Neurotrophic Factor - genetics
Brain-Derived Neurotrophic Factor - metabolism
Cricetinae
DBS technology
Deep brain stimulation
Deep Brain Stimulation - methods
Disease Models, Animal
Dystonia
Humans
Movement Disorders - genetics
Movement Disorders - metabolism
Movement Disorders - pathology
Movement Disorders - therapy
Parkinson's disease
Rats
Rodent models
Rodentia
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Summary:Deep brain stimulation (DBS) is the preferred treatment for therapy-resistant movement disorders such as dystonia and Parkinson's disease (PD), mostly in advanced disease stages. Although DBS is already in clinical use for ~30 years and has improved patients' quality of life dramatically, there is still limited understanding of the underlying mechanisms of action. Rodent models of PD and dystonia are essential tools to elucidate the mode of action of DBS on behavioral and multiscale neurobiological levels. Advances have been made in identifying DBS effects on the central motor network, neuroprotection and neuroinflammation in DBS studies of PD rodent models. The phenotypic dtsz mutant hamster and the transgenic DYT-TOR1A (ΔETorA) rat proved as valuable models of dystonia for preclinical DBS research. In addition, continuous refinements of rodent DBS technologies are ongoing and have contributed to improvement of experimental quality. We here review the currently existing literature on experimental DBS in PD and dystonia models regarding the choice of models, experimental design, neurobiological readouts, as well as methodological implications. Moreover, we provide an overview of the technical stage of existing DBS devices for use in rodent studies.
ISSN:0014-4886
1090-2430
DOI:10.1016/j.expneurol.2021.113926