Genetic polymorphism of circumsporozoite protein (CSP) in Plasmodium malariae isolates from Malaysia

Information about Plasmodium malariae is scanty worldwide due to its “benign” nature and low infection rates. Consequently, studies on the genetic polymorphisms of P. malariae are lacking. Here, we report genetic polymorphisms of 28 P. malariae circumsporozoite protein (Pmcsp) isolates from Malaysia...

Full description

Saved in:
Bibliographic Details
Published in:Parasitology international 2022-04, Vol.87, p.102519-102519, Article 102519
Main Authors: Phang, Wei Kit, Bukhari, Fatma Diyana Mohd, Zen, Lee Phone Youth, Jaimin, Joel Judson, Dony, Jiloris Julian Frederick, Lau, Yee Ling
Format: Article
Language:English
Subjects:
Amino Acid Sequence - genetics
Circumsporozoite protein
Malaria
Malaria - epidemiology
Malaria - parasitology
Malaysia
Malaysia - epidemiology
Nucleotides
Phylogeny
Plasmodium knowlesi - genetics
Plasmodium malariae
Plasmodium malariae - chemistry
Plasmodium malariae - classification
Plasmodium malariae - genetics
Polymorphism, Genetic
Protozoan Proteins - chemistry
Protozoan Proteins - genetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Information about Plasmodium malariae is scanty worldwide due to its “benign” nature and low infection rates. Consequently, studies on the genetic polymorphisms of P. malariae are lacking. Here, we report genetic polymorphisms of 28 P. malariae circumsporozoite protein (Pmcsp) isolates from Malaysia which were compared with those in other regions in Asia as well as those from Africa. Phylogenetic analysis revealed that most Malaysian P. malariae isolates clustered together but independently from other Asian isolates. Low nucleotide diversity was observed in Pmcsp non-repeat regions in contrast to high nucleotide diversity observed in non-repeat regions of Plasmodium knowlesi CSP gene, the current major cause of malaria in Malaysia. This study contributes to the characterisation of naturally occurring polymorphisms in the P. malariae CSP gene.
ISSN:1383-5769
1873-0329
DOI:10.1016/j.parint.2021.102519