Synthesis and cytotoxicity evaluation of alpha beta unsaturated carboxylic acids of thiophene analogs by using polymer supported microwave-assisted method

α- β unsaturated carboxylic acids containing a heterocyclic moiety is one of the most potent class of bioactive compounds whose speedy generation through novel synthetic techniques has become an enigma for the synthetic chemists. This research project demonstrates a novel method for the synthesis of...

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Bibliographic Details
Published in:Pakistan journal of pharmaceutical sciences 2021-07, Vol.34 (4), p.1403-1407
Main Authors: Hassan, Jhanara, Ehsan, Shahana, Shahnaz, -, Khan, Tahira Moen, Saghir, Tahira
Format: Article
Language:English
Subjects:
Amino acids
Carboxylic Acids - chemistry
Carboxylic Acids - toxicity
Cytotoxins - chemical synthesis
Cytotoxins - toxicity
Gas Chromatography-Mass Spectrometry
Hep G2 Cells - drug effects
Humans
Magnetic Resonance Spectroscopy
Methods
Microwaves
Polymer industry
Polymers
Spectroscopy, Fourier Transform Infrared
Thiophene
Thiophenes - chemical synthesis
Thiophenes - toxicity
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Summary:α- β unsaturated carboxylic acids containing a heterocyclic moiety is one of the most potent class of bioactive compounds whose speedy generation through novel synthetic techniques has become an enigma for the synthetic chemists. This research project demonstrates a novel method for the synthesis of these compounds using polymer-supported microwave-assisted methodology carried out through one-pot multicomponent reaction. Both soluble and insoluble polymers have been used and their results are comprehensively analyzed. Moreover, the compounds are characterized through spectral analysis like FTIR, GC-MASS, HNMR Spectroscopy. The cytotoxicity of synthesized compounds is evaluated through MTT assay using HEPG 2 cells.
ISSN:1011-601X
DOI:10.36721/PJPS.2021.34.4.REG.1403-1407.1