Emerging trends in point-of-care sensors for illicit drugs analysis

Consumption of illicit narcotic drugs and fatal or criminal activities under their influence has become an utmost concern worldwide. These drugs influence an individual's feelings, perceptions, and emotions by altering the state of consciousness and thus can result in serious safety breaches at...

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Published in:Talanta (Oxford) 2022-02, Vol.238 (Pt 2), p.123048-123048, Article 123048
Main Authors: Dagar, Manisha, Yadav, Sangeeta, Sai, V.V.R., Satija, Jitendra, Bhatia, Himanshu
Format: Article
Language:English
Subjects:
Biosensor
Cocaine
Dronabinol
Drug of abuse
Electrochemical sensor
Illicit drug
Illicit Drugs
Optical sensors
Point-of-Care Systems
Substance Abuse Detection
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Summary:Consumption of illicit narcotic drugs and fatal or criminal activities under their influence has become an utmost concern worldwide. These drugs influence an individual's feelings, perceptions, and emotions by altering the state of consciousness and thus can result in serious safety breaches at critical workplaces. Point-of-care drug-testing devices have become the need-of-the-hour for many sections such as the law enforcement agencies, the workplaces, etc. for safety and security. This review focuses on the recent progress on various electrochemical and optical nanosensors developed for the analysis of the most common illicit drugs (or their metabolites) such as tetrahydrocannabinol (THC), cocaine (COC), opioids (OPs), amphetamines & methamphetamine, and benzodiazepine (BZDs). The paper also highlights the sensitivity and selectivity of various sensing modalities along with evolving parameters such as real-time monitoring and measurement via a smart user interface. An overall outlook of recent technological advances in point of care (POC) devices and guided insights and directions for future research is presented. [Display omitted] •Detection of illicit drugs at roadside, workplace or clinical laboratories is of prime importance.•Nano-analytical methods have emerged as potential tools to detect illicit drugs down to picomolar to nanomolar level.•Electrochemical and optical platforms demonstrate potential towards development of highly sensitive and selective nanosensor.•Efforts are needed to translate the illicit drug detection nanobioassays into integrated real-time POCdiagnostics devices.
ISSN:0039-9140
1873-3573
DOI:10.1016/j.talanta.2021.123048