The versatile role of the contact system in cardiovascular disease, inflammation, sepsis and cancer

The human contact system consists of plasma proteins, which - after contact to foreign surfaces - are bound to them, thereby activating the zymogens of the system into enzymes. This activation mechanism gave the system its name - contact system. It is considered as a procoagulant and proinflammatory...

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Bibliographic Details
Published in:Biomedicine & pharmacotherapy 2022-01, Vol.145, p.112429-112429, Article 112429
Main Authors: Oehmcke-Hecht, Sonja, Berlin, Peggy, Müller-Hilke, Brigitte, Kreikemeyer, Bernd, Vasudevan, Praveen, Henze, Larissa, Khaimov, Valeria, Vollmar, Brigitte, David, Robert, Maletzki, Claudia
Format: Article
Language:English
Subjects:
Animals
Arthritis
Blood Proteins - metabolism
Bradykinin - metabolism
Cancer
Cardiovascular disease
Cardiovascular Diseases - physiopathology
Colitis
Contact system
Fibrin - metabolism
Humans
Inflammation - physiopathology
Neoplasms - pathology
Sepsis
Sepsis - physiopathology
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Summary:The human contact system consists of plasma proteins, which - after contact to foreign surfaces - are bound to them, thereby activating the zymogens of the system into enzymes. This activation mechanism gave the system its name - contact system. It is considered as a procoagulant and proinflammatory response mechanism, as activation finally leads to the generation of fibrin and bradykinin. To date, no physiological processes have been described that are mediated by contact activation. However, contact system factors play a pathophysiological role in numerous diseases, such as cardiovascular diseases, arthritis, colitis, sepsis, and cancer. Contact system factors are therefore an interesting target for new therapeutic options in different clinical conditions.
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2021.112429