Isoflurane as an Accurate Negative Mode Calibrant for Ion Mobility Spectrometry

The search for suitable ion mobility spectrometry (IMS) calibrant compounds is ongoing and necessitates the use of highly accurate reduced ion mobility (K 0) values across a range of instrumental conditions. Such values will be used in calibrating devices to shift the ion mobility scales and alarm w...

Full description

Saved in:
Bibliographic Details
Published in:Analytical chemistry (Washington) 2021-12, Vol.93 (48), p.16142-16148
Main Authors: Hauck, Brian C, Harden, Charles S, McHugh, Vincent M
Format: Article
Language:English
Subjects:
Analytical chemistry
Calibration
Chemistry
Electrophoretic mobility
Gas temperature
Instrumentation
Ion Mobility Spectrometry
Ionic mobility
Ions
Isoflurane
Negative ions
Positive ions
Scientific imaging
Spectrometry
Spectroscopy
Temperature
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The search for suitable ion mobility spectrometry (IMS) calibrant compounds is ongoing and necessitates the use of highly accurate reduced ion mobility (K 0) values across a range of instrumental conditions. Such values will be used in calibrating devices to shift the ion mobility scales and alarm windows for chemicals of interest to their proper locations based on the instrumental conditions present during calibration and sampling. Many positive ion mode calibrants have been investigated, whereas investigations for a negative ion detection mode calibrant have been more limited. Isoflurane (IsoF) is a strong candidate as a negative ion mode calibrant. This report documents the accurately measured K 0 values for IsoF product ions as a function of multiple instrumental parameters. K 0 values were measured in two instrumentation modes as a function of drift gas temperature, water concentration, and dopant concentration. This report culminates with our evaluation of the suitability of IsoF as a negative ion mode calibrant for IMS applications.
ISSN:0003-2700
1520-6882
DOI:10.1021/acs.analchem.1c03894