Long-term adherence to direct acting oral anticoagulants and the influence of health beliefs after switching from vitamin-K antagonists: Findings from the Switching Study

Switching non-adherent patients prescribed anticoagulant treatment to a regime with less monitoring could lead to significant non-adherence. Health beliefs are known to influence medication adherence; however, the extent of this influence is unknown in patients switched from vitamin-K antagonists (V...

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Bibliographic Details
Published in:Thrombosis research 2021-12, Vol.208, p.162-169
Main Authors: Bartoli-Abdou, John K., Patel, Jignesh P., Vadher, Bipin, Brown, Alison, Roberts, Lara N., Patel, Raj K., Arya, Roopen, Auyeung, Vivian
Format: Article
Language:English
Subjects:
Adherence
Anticoagulants - therapeutic use
Atrial fibrillation
Atrial Fibrillation - drug therapy
Beliefs
Direct oral anticoagulants
Factor Xa Inhibitors
Fibrinolytic Agents
Humans
Venous thromboembolism
Vitamin-K antagonists
Vitamins
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Summary:Switching non-adherent patients prescribed anticoagulant treatment to a regime with less monitoring could lead to significant non-adherence. Health beliefs are known to influence medication adherence; however, the extent of this influence is unknown in patients switched from vitamin-K antagonists (VKAs) to direct oral anticoagulants (DOACs). This study aimed to determine adherence to long-term therapy in patients switched from VKAs to DOAC due to low time in therapeutic range (TTR) and if adherence is associated with health beliefs. The Switching Study is a longitudinal observational cohort study following patients for at least 1-year. 254 patients anticoagulated with VKAs for stroke prevention in atrial fibrillation (AF) or secondary prevention of venous thromboembolism (VTE) and TTR 
ISSN:0049-3848
1879-2472
DOI:10.1016/j.thromres.2021.11.003