Effect of intraoperative fluid type on postoperative systemic inflammatory response and end organ dysfunction following total pancreatectomy with islet autotransplantation in children

• Published in: Journal of pediatric surgery 2022-08, Vol.57 (8), p.1649-1653
• Main Authors: Goddard, Gillian R., Wagner, Monica L., Jenkins, Todd M., Abu-El-Haija, Maisam, Lin, Tom K., Goldstein, Stuart L., Nathan, Jaimie D.
• Format: Article
• Language: English
• Subjects: Children; Intraoperative fluid type; Pediatrics; Systemic inflammatory response syndrome; Total pancreatectomy with islet autotransplantation
• ISSN: 0022-3468; 1531-5037
• DOI: 10.1016/j.jpedsurg.2021.10.013

•Intraoperative fluid type does not increase risk of postoperative SIRS.•Female sex, body mass index, operative length increase risk of postoperative SIRS.•Intraoperative fluid type is associated with increased acute kidney injury postoperatively. To evaluate the effect of intraoperative fluid type [half normal saline (0.45NS) or lactated Ringer's solution (LR)] on the risk of systemic inflammatory response syndrome (SIRS) and acute kidney injury after total pancreatectomy with islet autotransplantation in children. Retrospective review where demographics, operative details, systemic inflammatory response, and evaluation for end organ dysfunction over the first 5 postoperative days was obtained. Mixed effects Poisson regression compared risk of SIRS and acute kidney injury by intraoperative fluid type. Forty three patients were included with no difference in demographic characteristics between groups. SIRS was observed in 95, 77, and 71% over post operative days 1, 3, and 5. Intraoperative fluid type was found to not be associated with postoperative SIRS (RR: 0.91, p = 0.23). However, female sex (RR: 1.30, p