Spindle Cell Lipoma with Ossification Mimicking Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma: A Case Report

Although spindle cell lipoma (SCL) is a subtype of lipoma, the characteristics of SCL are observed in both lipomatous and non-lipomatous tumors. In this article, we present a case of SCL with ossification mimicking atypical lipomatous tumors/well-differentiated liposarcomas (ALTs/WDLs). Considering...

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Bibliographic Details
Published in:International journal of surgical pathology 2022-06, Vol.30 (4), p.413-418
Main Authors: Ichikawa, Jiro, Kawasaki, Tomonori, Imada, Hiroki, Enomoto, Atsushi, Taniguchi, Naofumi, Tatsuno, Rikito, Kanno, Satoshi, Haro, Hirotaka
Format: Article
Language:English
Subjects:
Cancer
Case reports
Cyclin-dependent kinases
Retina
Retinoblastoma
Tumors
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Summary:Although spindle cell lipoma (SCL) is a subtype of lipoma, the characteristics of SCL are observed in both lipomatous and non-lipomatous tumors. In this article, we present a case of SCL with ossification mimicking atypical lipomatous tumors/well-differentiated liposarcomas (ALTs/WDLs). Considering the findings of magnetic resonance imaging and needle biopsy, which exhibited ALTs/WDLs, marginal resection was performed. Histopathological findings demonstrated mature adipocytes and spindle cells without atypia and no malignant osteoid tissue in the ossified region. In addition, immunohistochemistry (IHC) showed positive staining for CD34, heterogeneous retinoblastoma protein deficiency, and negative staining for mouse double minute 2 homolog (MDM2) and cyclin-dependent kinase. Fluorescence in-situ hybridization showed negative amplification of MDM2. The final diagnosis of the tumor was established using IHC as an extremely rare SCL with ossification.
ISSN:1066-8969
1940-2465
DOI:10.1177/10668969211055798