Derivatizing merocyanine dyes to balance their polarity and viscosity sensitivities for protein aggregation detection

Protein misfolding and aggregation processes involve local polarity and viscosity fluctuation. Herein we modulated the polarity and viscosity sensitivities of merocyanine dyes to detect protein aggregation. We demonstrated how structural modulation balanced these two fluorescence sensitivities and a...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2021-12, Vol.57 (98), p.13313-13316
Main Authors: Bai, Yulong, Huang, Yanan, Wan, Wang, Jin, Wenhan, Shen, Di, Lyu, Haochen, Zeng, Lianggang, Liu, Yu
Format: Article
Language:English
Subjects:
Agglomeration
Benzopyrans - chemistry
Dyes
Fluorescence
Fluorescent Dyes
Humans
Indoles - chemistry
Molecular Structure
Protein Aggregation, Pathological - diagnosis
Proteins
Proteostasis Deficiencies - diagnosis
Viscosity
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Summary:Protein misfolding and aggregation processes involve local polarity and viscosity fluctuation. Herein we modulated the polarity and viscosity sensitivities of merocyanine dyes to detect protein aggregation. We demonstrated how structural modulation balanced these two fluorescence sensitivities and affected the detection of misfolded and aggregated proteins. Modulating the structure of merocyanine resulted in different environment-sensitivities and influenced the detection of protein aggregation.
ISSN:1359-7345
1364-548X
DOI:10.1039/d1cc05200d