Substituent Effect in Pyridinium Alkynylanthracenes on their Performance as Photosensitizers for Photodynamic Therapy

Progress in photodynamic therapy (PDT) relies on the design and synthesis of photosensitizers that can efficiently sensitize singlet oxygen using visible light irradiation while displaying limited dark toxicity. Here, we highlight the paper by Linker and coworkers published in this issue of Photoche...

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Bibliographic Details
Published in:Photochemistry and photobiology 2022-01, Vol.98 (1), p.272-274
Main Authors: Brega, Valentina, Thomas, Samuel W.
Format: Article
Language:English
Subjects:
HeLa Cells
Humans
Irradiation
Light irradiation
Photobiology
Photochemistry
Photochemotherapy
Photodynamic therapy
Photosensitizing Agents - therapeutic use
Pyridinium
Radiation
Singlet Oxygen
Toxicity
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Summary:Progress in photodynamic therapy (PDT) relies on the design and synthesis of photosensitizers that can efficiently sensitize singlet oxygen using visible light irradiation while displaying limited dark toxicity. Here, we highlight the paper by Linker and coworkers published in this issue of Photochemistry and Photobiology, which evaluates the effect of the regiochemistry of pyridinium rings in three isomeric pyridinium alkynylanthracenes on their performance as photosensitizers for PDT in HeLa cells. This highlight article describes the work of Linker and coworkers that addresses the regiochemical effect in pyridinium alkynylanthracenes on their performance as photosensitizers for photodynamic therapy. While the ortho isomer does not permeate through the cell membrane, the meta isomer targets the cell nucleus, and the para isomer targets the cellular cytoplasm.
ISSN:0031-8655
1751-1097
DOI:10.1111/php.13565