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Limosilactobacillus fermentum Strains with Claimed Probiotic Properties Exert Anti-oxidant and Anti-inflammatory Properties and Prevent Cardiometabolic Disorder in Female Rats Fed a High-Fat Diet
This study assessed the effects of a mixed formulation containing Limosilactobacillus ( L. ) fermentum 139, L. fermentum 263, and L. fermentum 296 on cardiometabolic parameters, inflammatory markers, short-chain fatty acid (SCFA) fecal contents, and oxidative stress in colon, liver, heart, and kidne...
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Published in: | Probiotics and antimicrobial proteins 2023-06, Vol.15 (3), p.601-613 |
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Main Authors: | , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | This study assessed the effects of a mixed formulation containing
Limosilactobacillus
(
L.
)
fermentum
139,
L. fermentum
263, and
L. fermentum
296 on cardiometabolic parameters, inflammatory markers, short-chain fatty acid (SCFA) fecal contents, and oxidative stress in colon, liver, heart, and kidney tissues of female rats fed a high-fat diet (HFD). Female Wistar rats were allocated into control diet (CTL,
n
= 6), HFD (
n
= 6), and HFD receiving
L. fermentum
formulation (HFD-LF,
n
= 6).
L. fermentum
formulation (1 × 10
9
CFU/mL of each strain) was administered two twice a day for 4 weeks. Administration of
L
.
fermentum
increased acetate and succinate fecal contents and reduced hyperlipidemia and hyperglycemia in rats fed a HFD (
p
|
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ISSN: | 1867-1306 1867-1314 |
DOI: | 10.1007/s12602-021-09878-1 |